The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis
The aim of the systematic review and meta-analysis was to evaluate the effects of conjugated linoleic acid (CLA) in metabolic syndrome (MS) patients. Randomized controlled trials (RCTs) conducted from inception to February 2015 were collected from seven databases. Among 1111 potentially relevant art...
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doaj-2d560f8bdc8d42b28af7fe05d1d9e4af2021-04-30T07:08:18ZengElsevierJournal of Functional Foods1756-46462016-08-0125588598The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysisBoyeon Kim0Ha Rae Lim1Heeyoung Lee2Hyangki Lee3Wonku Kang4Eunyoung Kim5Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chung-Ang University, Seoul 06974, South KoreaHospital and Clinical Pharmacy, The Graduate School of Food and Drug Administration, Chung-Ang University, Seoul 06974, South KoreaDepartment of Health, Social and Clinical Pharmacy, College of Pharmacy, Chung-Ang University, Seoul 06974, South KoreaThe Graduate School Pharmaceutical Management, Chung-Ang University, Seoul 06974, South Korea; Clinical Trial Center Asan Medical Center, Seoul 05505, South KoreaDepartment of Health, Social and Clinical Pharmacy, College of Pharmacy, Chung-Ang University, Seoul 06974, South Korea; Corresponding author. Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-gu, Seoul 06974, South Korea. Fax: +82 2 816 7338.Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chung-Ang University, Seoul 06974, South Korea; Corresponding author. Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chung-Ang University, 84, Heukseok-ro, Dongjak-gu, Seoul 06974, South Korea. Fax: +82 2 816 7338.The aim of the systematic review and meta-analysis was to evaluate the effects of conjugated linoleic acid (CLA) in metabolic syndrome (MS) patients. Randomized controlled trials (RCTs) conducted from inception to February 2015 were collected from seven databases. Among 1111 potentially relevant articles, nine RCTs (total 334 patients, 90% male) met inclusion criteria. A significant reduction in the CLA group in body weight and BMI (−0.51 kg [95% confidence interval (CI): −0.96, −0.07; p = 0.02] and −0.18 kg/m2 [95% CI: −0.32, −0.04; p = 0.01], respectively) was found compared to control. No effect was seen on blood pressure, insulin resistance, or triacylglycerol, but a reduction in HDL in the CLA group (−0.06 mmol/L [95% CI: −0.09, −0.03; p = 0.0002]) was found to be statistically and clinically significant. In MS patients, CLA was effective on weight loss and BMI, but adversely reduced HDL. Thus, precautions should be taken with CLA use for MS patients.http://www.sciencedirect.com/science/article/pii/S175646461630189XConjugated linoleic acidMetabolic syndromeObesityHigh density lipoproteinRandomized controlled trials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Boyeon Kim Ha Rae Lim Heeyoung Lee Hyangki Lee Wonku Kang Eunyoung Kim |
spellingShingle |
Boyeon Kim Ha Rae Lim Heeyoung Lee Hyangki Lee Wonku Kang Eunyoung Kim The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis Journal of Functional Foods Conjugated linoleic acid Metabolic syndrome Obesity High density lipoprotein Randomized controlled trials |
author_facet |
Boyeon Kim Ha Rae Lim Heeyoung Lee Hyangki Lee Wonku Kang Eunyoung Kim |
author_sort |
Boyeon Kim |
title |
The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis |
title_short |
The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis |
title_full |
The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis |
title_fullStr |
The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis |
title_full_unstemmed |
The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis |
title_sort |
effects of conjugated linoleic acid (cla) on metabolic syndrome patients: a systematic review and meta-analysis |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2016-08-01 |
description |
The aim of the systematic review and meta-analysis was to evaluate the effects of conjugated linoleic acid (CLA) in metabolic syndrome (MS) patients. Randomized controlled trials (RCTs) conducted from inception to February 2015 were collected from seven databases. Among 1111 potentially relevant articles, nine RCTs (total 334 patients, 90% male) met inclusion criteria. A significant reduction in the CLA group in body weight and BMI (−0.51 kg [95% confidence interval (CI): −0.96, −0.07; p = 0.02] and −0.18 kg/m2 [95% CI: −0.32, −0.04; p = 0.01], respectively) was found compared to control. No effect was seen on blood pressure, insulin resistance, or triacylglycerol, but a reduction in HDL in the CLA group (−0.06 mmol/L [95% CI: −0.09, −0.03; p = 0.0002]) was found to be statistically and clinically significant. In MS patients, CLA was effective on weight loss and BMI, but adversely reduced HDL. Thus, precautions should be taken with CLA use for MS patients. |
topic |
Conjugated linoleic acid Metabolic syndrome Obesity High density lipoprotein Randomized controlled trials |
url |
http://www.sciencedirect.com/science/article/pii/S175646461630189X |
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