PD-1 deficiency promotes TFH cells expansion in ITV-immunized mice by upregulating cytokines secretion

PD-1 deficiency promotes TFH cells expansion in ITV-immunized mice by upregulating cytokines secretion

Abstract Background T follicular helper (TFH) cells are fundamental for the development of humoral immunity. In our previous study, we found that PD-1 deficiency substantially promoted the expansion of Plasmodium-specific TFH cells and enhanced the humoral immunity of ITV (infection treatment vaccin...

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Bibliographic Details
Main Authors: Taiping Liu, Xiangyun Cheng, Yan Ding, Feng Zhu, Yong Fu, Xiaohong Peng, Wenyue Xu
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Parasites & Vectors
Subjects:
Malaria
Infection treatment vaccine
PD-1
Cytokines
TFH cells
Online Access:http://link.springer.com/article/10.1186/s13071-018-2984-4

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