MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS
Natural Killer (NK) cells are Innate Lymphoid Cells (ILC) with cytotoxic and regulatory properties. Their functions are tightly regulated by an array of inhibitory and activating receptors, and their mechanisms of activation strongly differ from antigen recognition in the context of HLA presentation...
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doaj-2d5ed148dc9a4ef881f1e099ef970ea52020-11-25T01:01:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-11-01710.3389/fimmu.2016.00504221876MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTSChristian CHABANNON0Christian CHABANNON1Bechara MFARREJ2Bechara MFARREJ3Sophie GUIA DA SILVA4Sophie UGOLINI5Raynier DEVILLIER6Didier BLAISE7Eric Vivier8Eric Vivier9Boris CALMELS10Boris CALMELS11 CBT-1409 : INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, AP-HMCRCM: INSERM, CNRS, Aix Marseille Univ, Institut Paoli-Calmettes CBT-1409 : INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, AP-HMCRCM: INSERM, CNRS, Aix Marseille Univ, Institut Paoli-CalmettesCentre d’Immunologie de Marseille-Luminy, Aix Marseille Univ, UM2, Inserm, U1104, CNRS UMR7280Centre d’Immunologie de Marseille-Luminy, Aix Marseille Univ, UM2, Inserm, U1104, CNRS UMR7280CRCM: INSERM, CNRS, Aix Marseille Univ, Institut Paoli-CalmettesCRCM: INSERM, CNRS, Aix Marseille Univ, Institut Paoli-CalmettesCentre d’Immunologie de Marseille-Luminy, Aix Marseille Univ, UM2, Inserm, U1104, CNRS UMR7280Assistance Publique des Hôpitaux de Marseille, AP-HM, CHU de Marseille CBT-1409 : INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, AP-HMCRCM: INSERM, CNRS, Aix Marseille Univ, Institut Paoli-CalmettesNatural Killer (NK) cells are Innate Lymphoid Cells (ILC) with cytotoxic and regulatory properties. Their functions are tightly regulated by an array of inhibitory and activating receptors, and their mechanisms of activation strongly differ from antigen recognition in the context of HLA presentation as needed for T-cell activation. NK cells thus offer unique opportunities for new and improved therapeutic manipulation, either in vivo or in vitro, in a variety of human diseases, including cancers. NK cell activity can possibly be modulated in vivo through direct or indirect actions exerted by small molecules or monoclonal antibodies. NK cells can also be adoptively transferred following more or less substantial modifications through cell and gene manufacturing, in order to empower them with new or improved functions and ensure their controlled persistence and activity in the recipient. In the present review, we will focus on the technological and regulatory challenges of NK cell manufacturing, and discuss conditions in which these innovative cellular therapies can be brought to the clinic.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00504/fullNatural Killer cells ; Innate Lymphoid Cells ; Immunotherapy ; Immuno-oncology ; Cellular therapy; Cell transplant ; Manufacturing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christian CHABANNON Christian CHABANNON Bechara MFARREJ Bechara MFARREJ Sophie GUIA DA SILVA Sophie UGOLINI Raynier DEVILLIER Didier BLAISE Eric Vivier Eric Vivier Boris CALMELS Boris CALMELS |
spellingShingle |
Christian CHABANNON Christian CHABANNON Bechara MFARREJ Bechara MFARREJ Sophie GUIA DA SILVA Sophie UGOLINI Raynier DEVILLIER Didier BLAISE Eric Vivier Eric Vivier Boris CALMELS Boris CALMELS MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS Frontiers in Immunology Natural Killer cells ; Innate Lymphoid Cells ; Immunotherapy ; Immuno-oncology ; Cellular therapy; Cell transplant ; Manufacturing |
author_facet |
Christian CHABANNON Christian CHABANNON Bechara MFARREJ Bechara MFARREJ Sophie GUIA DA SILVA Sophie UGOLINI Raynier DEVILLIER Didier BLAISE Eric Vivier Eric Vivier Boris CALMELS Boris CALMELS |
author_sort |
Christian CHABANNON |
title |
MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS |
title_short |
MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS |
title_full |
MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS |
title_fullStr |
MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS |
title_full_unstemmed |
MANUFACTURING NATURAL KILLER CELLS AS MEDICINAL PRODUCTS |
title_sort |
manufacturing natural killer cells as medicinal products |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2016-11-01 |
description |
Natural Killer (NK) cells are Innate Lymphoid Cells (ILC) with cytotoxic and regulatory properties. Their functions are tightly regulated by an array of inhibitory and activating receptors, and their mechanisms of activation strongly differ from antigen recognition in the context of HLA presentation as needed for T-cell activation. NK cells thus offer unique opportunities for new and improved therapeutic manipulation, either in vivo or in vitro, in a variety of human diseases, including cancers. NK cell activity can possibly be modulated in vivo through direct or indirect actions exerted by small molecules or monoclonal antibodies. NK cells can also be adoptively transferred following more or less substantial modifications through cell and gene manufacturing, in order to empower them with new or improved functions and ensure their controlled persistence and activity in the recipient. In the present review, we will focus on the technological and regulatory challenges of NK cell manufacturing, and discuss conditions in which these innovative cellular therapies can be brought to the clinic. |
topic |
Natural Killer cells ; Innate Lymphoid Cells ; Immunotherapy ; Immuno-oncology ; Cellular therapy; Cell transplant ; Manufacturing |
url |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00504/full |
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