Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model

Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model

Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounting for partial volume effects caused by free water...

Full description

Bibliographic Details
Main Authors: Anna Rydhög, Ofer Pasternak, Freddy Ståhlberg, André Ahlgren, Linda Knutsson, Ronnie Wirestam
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:European Journal of Radiology Open
Online Access:http://www.sciencedirect.com/science/article/pii/S2352047719300280
id doaj-2d6d4223fcce442da98ee61ebbacc028
record_format Article
spelling doaj-2d6d4223fcce442da98ee61ebbacc0282020-11-25T02:16:37ZengElsevierEuropean Journal of Radiology Open2352-04772019-01-016198205Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal modelAnna Rydhög0Ofer Pasternak1Freddy Ståhlberg2André Ahlgren3Linda Knutsson4Ronnie Wirestam5Department of Medical Radiation Physics, Lund University, Lund, SwedenDepartments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USADepartment of Medical Radiation Physics, Lund University, Lund, Sweden; Department of Diagnostic Radiology, Lund University, Lund, Sweden; Lund University Bioimaging Center, Lund University, Lund, SwedenDepartment of Medical Radiation Physics, Lund University, Lund, SwedenDepartment of Medical Radiation Physics, Lund University, Lund, Sweden; The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Medical Radiation Physics, Lund University, Lund, Sweden; Corresponding author at: Dept. of Medical Radiation Physics, Lund University, University Hospital, SE-22185 Lund, Sweden.Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounting for partial volume effects caused by free water and cerebrospinal fluid (CSF), or for tissue-dependent relaxation effects. In this work, a three-compartment model (tissue, free water and blood) that includes relaxation terms is introduced. To estimate the model parameters, in vivo human data were collected with multiple echo times (TE), inversion times (TI) and b-values, which allowed a direct relaxation estimate alongside estimation of perfusion, diffusion and fractional volume parameters. Compared to conventional two-compartment models (with and without relaxation compensation), the three-compartment model showed less effects of CSF contamination. The proposed model yielded significantly different volume fractions of blood and tissue compared to the non-relaxation-compensated model, as well as to the conventional two-compartment model, suggesting that previously reported parameter ranges, using models that do not account for relaxation, should be reconsidered. Keywords: Intravoxel incoherent motion, Perfusion fraction, Pseudo-diffusion, Relaxation, Diffusionhttp://www.sciencedirect.com/science/article/pii/S2352047719300280
collection DOAJ
language English
format Article
sources DOAJ
author Anna Rydhög
Ofer Pasternak
Freddy Ståhlberg
André Ahlgren
Linda Knutsson
Ronnie Wirestam
spellingShingle Anna Rydhög
Ofer Pasternak
Freddy Ståhlberg
André Ahlgren
Linda Knutsson
Ronnie Wirestam
Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model
European Journal of Radiology Open
author_facet Anna Rydhög
Ofer Pasternak
Freddy Ståhlberg
André Ahlgren
Linda Knutsson
Ronnie Wirestam
author_sort Anna Rydhög
title Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model
title_short Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model
title_full Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model
title_fullStr Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model
title_full_unstemmed Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model
title_sort estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (ivim) signal model
publisher Elsevier
series European Journal of Radiology Open
issn 2352-0477
publishDate 2019-01-01
description Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounting for partial volume effects caused by free water and cerebrospinal fluid (CSF), or for tissue-dependent relaxation effects. In this work, a three-compartment model (tissue, free water and blood) that includes relaxation terms is introduced. To estimate the model parameters, in vivo human data were collected with multiple echo times (TE), inversion times (TI) and b-values, which allowed a direct relaxation estimate alongside estimation of perfusion, diffusion and fractional volume parameters. Compared to conventional two-compartment models (with and without relaxation compensation), the three-compartment model showed less effects of CSF contamination. The proposed model yielded significantly different volume fractions of blood and tissue compared to the non-relaxation-compensated model, as well as to the conventional two-compartment model, suggesting that previously reported parameter ranges, using models that do not account for relaxation, should be reconsidered. Keywords: Intravoxel incoherent motion, Perfusion fraction, Pseudo-diffusion, Relaxation, Diffusion
url http://www.sciencedirect.com/science/article/pii/S2352047719300280
work_keys_str_mv AT annarydhog estimationofdiffusionperfusionandfractionalvolumesusingamulticompartmentrelaxationcompensatedintravoxelincoherentmotionivimsignalmodel
AT oferpasternak estimationofdiffusionperfusionandfractionalvolumesusingamulticompartmentrelaxationcompensatedintravoxelincoherentmotionivimsignalmodel
AT freddystahlberg estimationofdiffusionperfusionandfractionalvolumesusingamulticompartmentrelaxationcompensatedintravoxelincoherentmotionivimsignalmodel
AT andreahlgren estimationofdiffusionperfusionandfractionalvolumesusingamulticompartmentrelaxationcompensatedintravoxelincoherentmotionivimsignalmodel
AT lindaknutsson estimationofdiffusionperfusionandfractionalvolumesusingamulticompartmentrelaxationcompensatedintravoxelincoherentmotionivimsignalmodel
AT ronniewirestam estimationofdiffusionperfusionandfractionalvolumesusingamulticompartmentrelaxationcompensatedintravoxelincoherentmotionivimsignalmodel
_version_ 1724890125529251840

Similar Items