Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India

COVID-19 is an emerging viral disease affecting more than 200 countries worldwide and it present with varied clinical profile throughout the world. Without effective drugs to cure COVID-19, early identification and control of risk factors are important measures to combat COVID-19.  This study was c...

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Main Authors: Yamini Marimuthu, Radhika Kunnavil, NS Anil, Sharath Burugina Nagaraja, N Satyanarayana, Jeetendra Kumar, Bojja Ramya
Format: Article
Language:English
Published: PAGEPress Publications 2021-05-01
Series:Monaldi Archives for Chest Disease
Subjects:
Online Access:https://www.monaldi-archives.org/index.php/macd/article/view/1724
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spelling doaj-2d7108277eba42d69c29d2c3792a3b142021-05-18T04:15:09ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642021-05-0110.4081/monaldi.2021.1724Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, IndiaYamini Marimuthu0Radhika Kunnavil1NS Anil2Sharath Burugina Nagaraja3N Satyanarayana4Jeetendra Kumar5Bojja Ramya6Department of Community Medicine, ESIC Medical College & Post Graduate Institute of Medical Sciences and Research, Rajajinagar, Bengaluru Department of Community Medicine, ESIC Medical College & Post Graduate Institute of Medical Sciences and Research, Rajajinagar, Bengaluru Department of Community Medicine, ESIC Medical College & Post Graduate Institute of Medical Sciences and Research, Rajajinagar, Bengaluru Department of Community Medicine, ESIC Medical College & Post Graduate Institute of Medical Sciences and Research, Rajajinagar, Bengaluru Department of General Medicine, ESIC Medical College & Post Graduate Institute of Medical Sciences and Research, Rajajinagar, BengaluruESIC Medical College & Post Graduate Institute of Medical Sciences and Research, Rajajinagar, BengaluruESIC Medical College & Post Graduate Institute of Medical Sciences and Research, Rajajinagar, Bengaluru COVID-19 is an emerging viral disease affecting more than 200 countries worldwide and it present with varied clinical profile throughout the world. Without effective drugs to cure COVID-19, early identification and control of risk factors are important measures to combat COVID-19.  This study was conducted to determine the clinical profile and risk factors associated with mortality among COVID-19 patients in a tertiary care hospital in South India. This record-based longitudinal study was conducted by reviewing the case records of COVID-19 patients admitted for treatment from June 2020 to September 2020 in a tertiary care centre in South India. The clinical details, discharge/death details, were collected and entered in MS Excel. Potential risk factors for COVID-19 mortality were analysed using univariate binomial logistic regression, generalized linear models (GLM) with Poisson distribution. Survival curves were made using the Kaplan-Meier method. Log-rank test was used to test the equality of survivor functions between the groups. Out of 854 COVID-19 patients, 56.6% were men and the mean (standard deviation) age was 45.3(17.2) years. The median survival time was significantly lesser in male COVID-19 patients (16 days) as compared to female patients (20 days). Increasing age, male gender, patients presenting with symptoms of fever, cough, breathlessness, smoking, alcohol consumption, comorbidities were significantly associated with mortality among COVID-19 patients. Patients with older age, male gender, breathlessness, fever, cough, smoking and alcohol and comorbidities need careful observation and early intervention.  Public health campaigns aimed at reducing the prevalence of risk factors like diabetes, hypertension, smoking and alcohol use are also needed. https://www.monaldi-archives.org/index.php/macd/article/view/1724COVID-19SARS CoV-2risk factorssurvival analysismortality
collection DOAJ
language English
format Article
sources DOAJ
author Yamini Marimuthu
Radhika Kunnavil
NS Anil
Sharath Burugina Nagaraja
N Satyanarayana
Jeetendra Kumar
Bojja Ramya
spellingShingle Yamini Marimuthu
Radhika Kunnavil
NS Anil
Sharath Burugina Nagaraja
N Satyanarayana
Jeetendra Kumar
Bojja Ramya
Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India
Monaldi Archives for Chest Disease
COVID-19
SARS CoV-2
risk factors
survival analysis
mortality
author_facet Yamini Marimuthu
Radhika Kunnavil
NS Anil
Sharath Burugina Nagaraja
N Satyanarayana
Jeetendra Kumar
Bojja Ramya
author_sort Yamini Marimuthu
title Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India
title_short Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India
title_full Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India
title_fullStr Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India
title_full_unstemmed Clinical profile and risk factors for mortality among COVID-19 inpatients at a tertiary care centre in Bengaluru, India
title_sort clinical profile and risk factors for mortality among covid-19 inpatients at a tertiary care centre in bengaluru, india
publisher PAGEPress Publications
series Monaldi Archives for Chest Disease
issn 1122-0643
2532-5264
publishDate 2021-05-01
description COVID-19 is an emerging viral disease affecting more than 200 countries worldwide and it present with varied clinical profile throughout the world. Without effective drugs to cure COVID-19, early identification and control of risk factors are important measures to combat COVID-19.  This study was conducted to determine the clinical profile and risk factors associated with mortality among COVID-19 patients in a tertiary care hospital in South India. This record-based longitudinal study was conducted by reviewing the case records of COVID-19 patients admitted for treatment from June 2020 to September 2020 in a tertiary care centre in South India. The clinical details, discharge/death details, were collected and entered in MS Excel. Potential risk factors for COVID-19 mortality were analysed using univariate binomial logistic regression, generalized linear models (GLM) with Poisson distribution. Survival curves were made using the Kaplan-Meier method. Log-rank test was used to test the equality of survivor functions between the groups. Out of 854 COVID-19 patients, 56.6% were men and the mean (standard deviation) age was 45.3(17.2) years. The median survival time was significantly lesser in male COVID-19 patients (16 days) as compared to female patients (20 days). Increasing age, male gender, patients presenting with symptoms of fever, cough, breathlessness, smoking, alcohol consumption, comorbidities were significantly associated with mortality among COVID-19 patients. Patients with older age, male gender, breathlessness, fever, cough, smoking and alcohol and comorbidities need careful observation and early intervention.  Public health campaigns aimed at reducing the prevalence of risk factors like diabetes, hypertension, smoking and alcohol use are also needed.
topic COVID-19
SARS CoV-2
risk factors
survival analysis
mortality
url https://www.monaldi-archives.org/index.php/macd/article/view/1724
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