Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding.
To fully understand the glycolytic behavior of cancer cells, it is important to recognize how it is linked to pH dynamics. Here, we evaluated the acute effects of mild acidification and alkalization on cancer cell glucose uptake and glycolytic flux and investigated the role of hexokinase (HK). Cance...
Main Authors: | Cung Hoa Thien Quach, Kyung-Ho Jung, Jin Hee Lee, Jin Won Park, Seung Hwan Moon, Young Seok Cho, Yearn Seong Choe, Kyung-Han Lee |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4968818?pdf=render |
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