Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice
Background: The diagnosis of lymphoma requires surgical specimens to perform morphological evaluation, immunohistochemical and molecular analyses. Ultrasound-guided fine needle aspiration may represent an appropriate first approach to obtain cytological samples in impalpable lesions and/or in patien...
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doaj-2d901299558549a1a954ee1d2f561c102020-11-25T03:52:39ZengMDPI AGDiagnostics2075-44182020-09-011074874810.3390/diagnostics10100748Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic PracticePaola Parente0Claudia Covelli1Magda Zanelli2Domenico Trombetta3Illuminato Carosi4Cristiano Carbonelli5Marco Sperandeo6Luca Mastracci7Giovanni Biancofiore8Maurizio Zizzo9Marco Taurchini10Stefano Ascani11Paolo Graziano12Pathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyPathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyPathology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyLaboratory of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyPathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyUnit of Interventional Pulmonology, Department of Internal Medicine, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyUnit of Interventional and Diagnostic Ultrasound of Internal Medicine, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyAnatomic Pathology, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16132 Genova, ItalyPathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalySurgical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyThoracic Surgical Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyPathology Unit, Hospital of Terni and University of Perugia, 05100 Terni, ItalyPathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, ItalyBackground: The diagnosis of lymphoma requires surgical specimens to perform morphological evaluation, immunohistochemical and molecular analyses. Ultrasound-guided fine needle aspiration may represent an appropriate first approach to obtain cytological samples in impalpable lesions and/or in patients unsuitable for surgical procedures. Although cytology has intrinsic limitations, the cell block method may increase the possibility of achieving an accurate diagnosis. Methods: We retrospectively selected a total of 47 ultrasound-guided fine needle aspiration and drainage samples taken from patients with effusion and deep-seated lesions which are clinically suspicious in terms of malignancy. Results: In 27 cases, both cell block and conventional cytology were performed: 21/27 cell blocks were adequate for the diagnosis of lymphoma and suitable for immunocytochemistry and molecular analyses vs. 12/20 samples to which only conventional cytology was applied. Moreover, in five patients we were able to make a diagnosis of Hodgkin lymphoma with the cell block (CB) technique. Conclusions: Contrary to conventional cytology, the cell block method may allow immunocytochemistry and molecular studies providing useful information for the diagnosis and subtypization of lymphoma in patients unsuitable for surgical procedure or with deep-seated lesions or extra-nodal diseases; additionally, it is a daily, simple and helpful approach. Moreover, we describe the usefulness of cell blocks in the diagnosis of Hodgkin lymphoma.https://www.mdpi.com/2075-4418/10/10/748cell blockcytologyHodgkin lymphomanon-Hodgkin lymphomaEBUS-FNAUS-FNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paola Parente Claudia Covelli Magda Zanelli Domenico Trombetta Illuminato Carosi Cristiano Carbonelli Marco Sperandeo Luca Mastracci Giovanni Biancofiore Maurizio Zizzo Marco Taurchini Stefano Ascani Paolo Graziano |
spellingShingle |
Paola Parente Claudia Covelli Magda Zanelli Domenico Trombetta Illuminato Carosi Cristiano Carbonelli Marco Sperandeo Luca Mastracci Giovanni Biancofiore Maurizio Zizzo Marco Taurchini Stefano Ascani Paolo Graziano Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice Diagnostics cell block cytology Hodgkin lymphoma non-Hodgkin lymphoma EBUS-FNA US-FNA |
author_facet |
Paola Parente Claudia Covelli Magda Zanelli Domenico Trombetta Illuminato Carosi Cristiano Carbonelli Marco Sperandeo Luca Mastracci Giovanni Biancofiore Maurizio Zizzo Marco Taurchini Stefano Ascani Paolo Graziano |
author_sort |
Paola Parente |
title |
Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice |
title_short |
Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice |
title_full |
Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice |
title_fullStr |
Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice |
title_full_unstemmed |
Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in “Selected” Diagnostic Practice |
title_sort |
diagnosis of hodgkin lymphoma from cell block: a reliable and helpful tool in “selected” diagnostic practice |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-09-01 |
description |
Background: The diagnosis of lymphoma requires surgical specimens to perform morphological evaluation, immunohistochemical and molecular analyses. Ultrasound-guided fine needle aspiration may represent an appropriate first approach to obtain cytological samples in impalpable lesions and/or in patients unsuitable for surgical procedures. Although cytology has intrinsic limitations, the cell block method may increase the possibility of achieving an accurate diagnosis. Methods: We retrospectively selected a total of 47 ultrasound-guided fine needle aspiration and drainage samples taken from patients with effusion and deep-seated lesions which are clinically suspicious in terms of malignancy. Results: In 27 cases, both cell block and conventional cytology were performed: 21/27 cell blocks were adequate for the diagnosis of lymphoma and suitable for immunocytochemistry and molecular analyses vs. 12/20 samples to which only conventional cytology was applied. Moreover, in five patients we were able to make a diagnosis of Hodgkin lymphoma with the cell block (CB) technique. Conclusions: Contrary to conventional cytology, the cell block method may allow immunocytochemistry and molecular studies providing useful information for the diagnosis and subtypization of lymphoma in patients unsuitable for surgical procedure or with deep-seated lesions or extra-nodal diseases; additionally, it is a daily, simple and helpful approach. Moreover, we describe the usefulness of cell blocks in the diagnosis of Hodgkin lymphoma. |
topic |
cell block cytology Hodgkin lymphoma non-Hodgkin lymphoma EBUS-FNA US-FNA |
url |
https://www.mdpi.com/2075-4418/10/10/748 |
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