Genetic lineage tracing defines myofibroblast origin and function in the injured heart
The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessary for scar formation after injury, and can revert...
Main Authors: | Onur Kanisicak, Hadi Khalil, Malina J. Ivey, Jason Karch, Bryan D. Maliken, Robert N. Correll, Matthew J. Brody, Suh-Chin J. Lin, Bruce J. Aronow, Michelle D. Tallquist, Jeffery D. Molkentin |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12260 |
Similar Items
-
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
by: Jason Karch, et al.
Published: (2017-11-01) -
Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.
by: Jason Karch, et al.
Published: (2015-01-01) -
Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast∗
by: Onur Kanisicak, PhD, et al.
Published: (2016-12-01) -
Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response.
by: Jop H van Berlo, et al.
Published: (2013-01-01) -
Bone marrow derived cells contribute to myofibroblast populations in injured and neoplastic tissue
by: Direkze, Natalie Chantelle
Published: (2006)