The regulation of apoptosis in kidney development: implications for nephron number and pattern?
Apoptosis is essential to remodel developing structures and eliminate superfluous cells in a controlled manner during normal development, and continues to be an important component of tissue remodeling and regeneration during an organism’s lifespan, or as a response to injury. This mini-review will...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-11-01
|
Series: | Frontiers in Pediatrics |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fped.2014.00128/full |
id |
doaj-2d9ab59625c24d95944f80918567a17c |
---|---|
record_format |
Article |
spelling |
doaj-2d9ab59625c24d95944f80918567a17c2020-11-24T22:49:32ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602014-11-01210.3389/fped.2014.00128122248The regulation of apoptosis in kidney development: implications for nephron number and pattern?Jacqueline eHo0Children's Hospital of Pittsburgh of UPMCApoptosis is essential to remodel developing structures and eliminate superfluous cells in a controlled manner during normal development, and continues to be an important component of tissue remodeling and regeneration during an organism’s lifespan, or as a response to injury. This mini-review will discuss recent studies that have provided insights into the roles of apoptosis in the determination of nephron number and pattern, during normal and abnormal kidney development. The regulation of congenital nephron endowment has implications for risk of chronic kidney disease in later life, whereas abnormalities in nephron pattern are associated with congenital anomalies of the kidney and urinary tract (the leading cause of renal disease in children). Tight regulation of apoptosis is required in normal renal morphogenesis, although many questions remain regarding the regulation of apoptosis by genetic, epigenetic and environmental factors, in addition to the functional requirement of different components of the apoptotic pathway.http://journal.frontiersin.org/Journal/10.3389/fped.2014.00128/fullApoptosiskidney developmentnephron numberCystic kidney diseasenephron pattern |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jacqueline eHo |
spellingShingle |
Jacqueline eHo The regulation of apoptosis in kidney development: implications for nephron number and pattern? Frontiers in Pediatrics Apoptosis kidney development nephron number Cystic kidney disease nephron pattern |
author_facet |
Jacqueline eHo |
author_sort |
Jacqueline eHo |
title |
The regulation of apoptosis in kidney development: implications for nephron number and pattern? |
title_short |
The regulation of apoptosis in kidney development: implications for nephron number and pattern? |
title_full |
The regulation of apoptosis in kidney development: implications for nephron number and pattern? |
title_fullStr |
The regulation of apoptosis in kidney development: implications for nephron number and pattern? |
title_full_unstemmed |
The regulation of apoptosis in kidney development: implications for nephron number and pattern? |
title_sort |
regulation of apoptosis in kidney development: implications for nephron number and pattern? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2014-11-01 |
description |
Apoptosis is essential to remodel developing structures and eliminate superfluous cells in a controlled manner during normal development, and continues to be an important component of tissue remodeling and regeneration during an organism’s lifespan, or as a response to injury. This mini-review will discuss recent studies that have provided insights into the roles of apoptosis in the determination of nephron number and pattern, during normal and abnormal kidney development. The regulation of congenital nephron endowment has implications for risk of chronic kidney disease in later life, whereas abnormalities in nephron pattern are associated with congenital anomalies of the kidney and urinary tract (the leading cause of renal disease in children). Tight regulation of apoptosis is required in normal renal morphogenesis, although many questions remain regarding the regulation of apoptosis by genetic, epigenetic and environmental factors, in addition to the functional requirement of different components of the apoptotic pathway. |
topic |
Apoptosis kidney development nephron number Cystic kidney disease nephron pattern |
url |
http://journal.frontiersin.org/Journal/10.3389/fped.2014.00128/full |
work_keys_str_mv |
AT jacquelineeho theregulationofapoptosisinkidneydevelopmentimplicationsfornephronnumberandpattern AT jacquelineeho regulationofapoptosisinkidneydevelopmentimplicationsfornephronnumberandpattern |
_version_ |
1725675839485378560 |