Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses
Mast cells are tissue-resident innate immune cells known for their prominent role in mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a promiscuous G-protein coupled receptor (GPCR) expressed on mast cells that is activated by several ligands that share cationic a...
Main Authors: | Brianna N. Callahan, Ananth K. Kammala, Meesum Syed, Canchai Yang, Christopher J. Occhiuto, Rithvik Nellutla, Alena P. Chumanevich, Carole A. Oskeritzian, Rupali Das, Hariharan Subramanian |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-04-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00703/full |
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