A “reverse pharmacology” approach for developing an anti-malarial phytomedicine
<p>Abstract</p> <p>A “reverse pharmacology” approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a...
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2011-03-01
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Series: | Malaria Journal |
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doaj-2d9bfcd3a25040339612f8a93a0ed1522020-11-24T21:18:28ZengBMCMalaria Journal1475-28752011-03-0110Suppl 1S810.1186/1475-2875-10-S1-S8A “reverse pharmacology” approach for developing an anti-malarial phytomedicineDiakite ChiakaFalquet JacquesGraz BertrandWillcox Merlin LGiani SergioDiallo Drissa<p>Abstract</p> <p>A “reverse pharmacology” approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-outcome study. The second step was a dose-escalating clinical trial that showed a dose-response phenomenon and helped select the safest and most efficacious dose. The third step was a randomized controlled trial to compare the phytomedicine to the standard first-line treatment. The last step was to identify active compounds which can be used as markers for standardization and quality control. This example of “reverse pharmacology” shows that a standardized phytomedicine can be developed faster and more cheaply than conventional drugs. Even if both approaches are not fully comparable, their efficiency in terms of public health and their complementarity should be thoroughly considered.</p> http://www.malariajournal.com/content/10/S1/S8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diakite Chiaka Falquet Jacques Graz Bertrand Willcox Merlin L Giani Sergio Diallo Drissa |
spellingShingle |
Diakite Chiaka Falquet Jacques Graz Bertrand Willcox Merlin L Giani Sergio Diallo Drissa A “reverse pharmacology” approach for developing an anti-malarial phytomedicine Malaria Journal |
author_facet |
Diakite Chiaka Falquet Jacques Graz Bertrand Willcox Merlin L Giani Sergio Diallo Drissa |
author_sort |
Diakite Chiaka |
title |
A “reverse pharmacology” approach for developing an anti-malarial phytomedicine |
title_short |
A “reverse pharmacology” approach for developing an anti-malarial phytomedicine |
title_full |
A “reverse pharmacology” approach for developing an anti-malarial phytomedicine |
title_fullStr |
A “reverse pharmacology” approach for developing an anti-malarial phytomedicine |
title_full_unstemmed |
A “reverse pharmacology” approach for developing an anti-malarial phytomedicine |
title_sort |
“reverse pharmacology” approach for developing an anti-malarial phytomedicine |
publisher |
BMC |
series |
Malaria Journal |
issn |
1475-2875 |
publishDate |
2011-03-01 |
description |
<p>Abstract</p> <p>A “reverse pharmacology” approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-outcome study. The second step was a dose-escalating clinical trial that showed a dose-response phenomenon and helped select the safest and most efficacious dose. The third step was a randomized controlled trial to compare the phytomedicine to the standard first-line treatment. The last step was to identify active compounds which can be used as markers for standardization and quality control. This example of “reverse pharmacology” shows that a standardized phytomedicine can be developed faster and more cheaply than conventional drugs. Even if both approaches are not fully comparable, their efficiency in terms of public health and their complementarity should be thoroughly considered.</p> |
url |
http://www.malariajournal.com/content/10/S1/S8 |
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