PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging
Impaired muscle recovery (size and strength) following a disuse period commonly occurs in older adults. Many of these individuals are not able to adequately exercise due to pain and logistic barriers. Thus, nutritional and pharmacological therapeutics, that are translatable, are needed to promote mu...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-4601/17/22/8650 |
id |
doaj-2d9e14778f124897a26493a4d0e7cfcd |
---|---|
record_format |
Article |
spelling |
doaj-2d9e14778f124897a26493a4d0e7cfcd2020-11-25T04:10:06ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-11-01178650865010.3390/ijerph17228650PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in AgingJonathan J. Petrocelli0Micah J. Drummond1Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USADepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USAImpaired muscle recovery (size and strength) following a disuse period commonly occurs in older adults. Many of these individuals are not able to adequately exercise due to pain and logistic barriers. Thus, nutritional and pharmacological therapeutics, that are translatable, are needed to promote muscle recovery following disuse in older individuals. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may be a suitable therapeutic target due to pleiotropic regulation of skeletal muscle. This review focuses on nutritional and pharmacological interventions that target PGC-1α and related Sirtuin 1 (SIRT1) and 5′ AMP-activated protein kinase (AMPKα) signaling in muscle and thus may be rapidly translated to prevent muscle disuse atrophy and promote recovery. In this review, we present several therapeutics that target PGC-1α in skeletal muscle such as leucine, β-hydroxy-β-methylbuyrate (HMB), arginine, resveratrol, metformin and combination therapies that may have future application to conditions of disuse and recovery in humans.https://www.mdpi.com/1660-4601/17/22/8650disusesarcopeniametforminleucineresveratrolskeletal muscle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan J. Petrocelli Micah J. Drummond |
spellingShingle |
Jonathan J. Petrocelli Micah J. Drummond PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging International Journal of Environmental Research and Public Health disuse sarcopenia metformin leucine resveratrol skeletal muscle |
author_facet |
Jonathan J. Petrocelli Micah J. Drummond |
author_sort |
Jonathan J. Petrocelli |
title |
PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
title_short |
PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
title_full |
PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
title_fullStr |
PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
title_full_unstemmed |
PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging |
title_sort |
pgc-1α-targeted therapeutic approaches to enhance muscle recovery in aging |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-11-01 |
description |
Impaired muscle recovery (size and strength) following a disuse period commonly occurs in older adults. Many of these individuals are not able to adequately exercise due to pain and logistic barriers. Thus, nutritional and pharmacological therapeutics, that are translatable, are needed to promote muscle recovery following disuse in older individuals. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may be a suitable therapeutic target due to pleiotropic regulation of skeletal muscle. This review focuses on nutritional and pharmacological interventions that target PGC-1α and related Sirtuin 1 (SIRT1) and 5′ AMP-activated protein kinase (AMPKα) signaling in muscle and thus may be rapidly translated to prevent muscle disuse atrophy and promote recovery. In this review, we present several therapeutics that target PGC-1α in skeletal muscle such as leucine, β-hydroxy-β-methylbuyrate (HMB), arginine, resveratrol, metformin and combination therapies that may have future application to conditions of disuse and recovery in humans. |
topic |
disuse sarcopenia metformin leucine resveratrol skeletal muscle |
url |
https://www.mdpi.com/1660-4601/17/22/8650 |
work_keys_str_mv |
AT jonathanjpetrocelli pgc1atargetedtherapeuticapproachestoenhancemusclerecoveryinaging AT micahjdrummond pgc1atargetedtherapeuticapproachestoenhancemusclerecoveryinaging |
_version_ |
1724420721610850304 |