A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.

Bibliographic Details
Main Authors:	Fang Qiu, Ruqi Tang, Xianbo Zuo, Xingjuan Shi, Yiran Wei, Xiaodong Zheng, Yaping Dai, Yuhua Gong, Lan Wang, Ping Xu, Xiang Zhu, Jian Wu, Chongxu Han, Yueqiu Gao, Kui Zhang, Yuzhang Jiang, Jianbo Zhou, Youlin Shao, Zhigang Hu, Ye Tian, Haiyan Zhang, Na Dai, Lei Liu, Xudong Wu, Weifeng Zhao, Xiaomin Zhang, Zhidong Zang, Jinshan Nie, Weihao Sun, Yi Zhao, Yuan Mao, Po Jiang, Hualiang Ji, Qing Dong, Junming Li, Zhenzhong Li, Xinli Bai, Li Li, Maosong Lin, Ming Dong, Jinxin Li, Ping Zhu, Chan Wang, Yanqiu Zhang, Peng Jiang, Yujue Wang, Rohil Jawed, Jing Xu, Yu Zhang, Qixia Wang, Yue Yang, Fan Yang, Min Lian, Xiang Jiang, Xiao Xiao, Yanmei Li, Jingyuan Fang, Dekai Qiu, Zhen Zhu, Hong Qiu, Jianqiong Zhang, Wenyan Tian, Sufang Chen, Ling Jiang, Bing Ji, Ping Li, Guochang Chen, Tianxue Wu, Yan Sun, Jianjiang Yu, Huijun Tang, Michun He, Min Xia, Hao Pei, Lihua Huang, Zhuye Qing, Jianfang Wu, Qinghai Huang, Junhai Han, Wei Xie, Zhongsheng Sun, Jian Guo, Gengsheng He, M. Eric Gershwin, Zhexiong Lian, Xiang Liu, Michael F. Seldin, Xiangdong Liu, Weichang Chen, Xiong Ma
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14828

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collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fang Qiu Ruqi Tang Xianbo Zuo Xingjuan Shi Yiran Wei Xiaodong Zheng Yaping Dai Yuhua Gong Lan Wang Ping Xu Xiang Zhu Jian Wu Chongxu Han Yueqiu Gao Kui Zhang Yuzhang Jiang Jianbo Zhou Youlin Shao Zhigang Hu Ye Tian Haiyan Zhang Na Dai Lei Liu Xudong Wu Weifeng Zhao Xiaomin Zhang Zhidong Zang Jinshan Nie Weihao Sun Yi Zhao Yuan Mao Po Jiang Hualiang Ji Qing Dong Junming Li Zhenzhong Li Xinli Bai Li Li Maosong Lin Ming Dong Jinxin Li Ping Zhu Chan Wang Yanqiu Zhang Peng Jiang Yujue Wang Rohil Jawed Jing Xu Yu Zhang Qixia Wang Yue Yang Fan Yang Min Lian Xiang Jiang Xiao Xiao Yanmei Li Jingyuan Fang Dekai Qiu Zhen Zhu Hong Qiu Jianqiong Zhang Wenyan Tian Sufang Chen Ling Jiang Bing Ji Ping Li Guochang Chen Tianxue Wu Yan Sun Jianjiang Yu Huijun Tang Michun He Min Xia Hao Pei Lihua Huang Zhuye Qing Jianfang Wu Qinghai Huang Junhai Han Wei Xie Zhongsheng Sun Jian Guo Gengsheng He M. Eric Gershwin Zhexiong Lian Xiang Liu Michael F. Seldin Xiangdong Liu Weichang Chen Xiong Ma
spellingShingle	Fang Qiu Ruqi Tang Xianbo Zuo Xingjuan Shi Yiran Wei Xiaodong Zheng Yaping Dai Yuhua Gong Lan Wang Ping Xu Xiang Zhu Jian Wu Chongxu Han Yueqiu Gao Kui Zhang Yuzhang Jiang Jianbo Zhou Youlin Shao Zhigang Hu Ye Tian Haiyan Zhang Na Dai Lei Liu Xudong Wu Weifeng Zhao Xiaomin Zhang Zhidong Zang Jinshan Nie Weihao Sun Yi Zhao Yuan Mao Po Jiang Hualiang Ji Qing Dong Junming Li Zhenzhong Li Xinli Bai Li Li Maosong Lin Ming Dong Jinxin Li Ping Zhu Chan Wang Yanqiu Zhang Peng Jiang Yujue Wang Rohil Jawed Jing Xu Yu Zhang Qixia Wang Yue Yang Fan Yang Min Lian Xiang Jiang Xiao Xiao Yanmei Li Jingyuan Fang Dekai Qiu Zhen Zhu Hong Qiu Jianqiong Zhang Wenyan Tian Sufang Chen Ling Jiang Bing Ji Ping Li Guochang Chen Tianxue Wu Yan Sun Jianjiang Yu Huijun Tang Michun He Min Xia Hao Pei Lihua Huang Zhuye Qing Jianfang Wu Qinghai Huang Junhai Han Wei Xie Zhongsheng Sun Jian Guo Gengsheng He M. Eric Gershwin Zhexiong Lian Xiang Liu Michael F. Seldin Xiangdong Liu Weichang Chen Xiong Ma A genome-wide association study identifies six novel risk loci for primary biliary cholangitis Nature Communications
author_facet	Fang Qiu Ruqi Tang Xianbo Zuo Xingjuan Shi Yiran Wei Xiaodong Zheng Yaping Dai Yuhua Gong Lan Wang Ping Xu Xiang Zhu Jian Wu Chongxu Han Yueqiu Gao Kui Zhang Yuzhang Jiang Jianbo Zhou Youlin Shao Zhigang Hu Ye Tian Haiyan Zhang Na Dai Lei Liu Xudong Wu Weifeng Zhao Xiaomin Zhang Zhidong Zang Jinshan Nie Weihao Sun Yi Zhao Yuan Mao Po Jiang Hualiang Ji Qing Dong Junming Li Zhenzhong Li Xinli Bai Li Li Maosong Lin Ming Dong Jinxin Li Ping Zhu Chan Wang Yanqiu Zhang Peng Jiang Yujue Wang Rohil Jawed Jing Xu Yu Zhang Qixia Wang Yue Yang Fan Yang Min Lian Xiang Jiang Xiao Xiao Yanmei Li Jingyuan Fang Dekai Qiu Zhen Zhu Hong Qiu Jianqiong Zhang Wenyan Tian Sufang Chen Ling Jiang Bing Ji Ping Li Guochang Chen Tianxue Wu Yan Sun Jianjiang Yu Huijun Tang Michun He Min Xia Hao Pei Lihua Huang Zhuye Qing Jianfang Wu Qinghai Huang Junhai Han Wei Xie Zhongsheng Sun Jian Guo Gengsheng He M. Eric Gershwin Zhexiong Lian Xiang Liu Michael F. Seldin Xiangdong Liu Weichang Chen Xiong Ma
author_sort	Fang Qiu
title	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_short	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_full	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_fullStr	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_full_unstemmed	A genome-wide association study identifies six novel risk loci for primary biliary cholangitis
title_sort	genome-wide association study identifies six novel risk loci for primary biliary cholangitis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-04-01
description	Primary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.
url	https://doi.org/10.1038/ncomms14828
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spelling	doaj-2d9f1e41b1654d168ba642000f183a482021-05-11T07:27:26ZengNature Publishing GroupNature Communications2041-17232017-04-01811810.1038/ncomms14828A genome-wide association study identifies six novel risk loci for primary biliary cholangitisFang Qiu0Ruqi Tang1Xianbo Zuo2Xingjuan Shi3Yiran Wei4Xiaodong Zheng5Yaping Dai6Yuhua Gong7Lan Wang8Ping Xu9Xiang Zhu10Jian Wu11Chongxu Han12Yueqiu Gao13Kui Zhang14Yuzhang Jiang15Jianbo Zhou16Youlin Shao17Zhigang Hu18Ye Tian19Haiyan Zhang20Na Dai21Lei Liu22Xudong Wu23Weifeng Zhao24Xiaomin Zhang25Zhidong Zang26Jinshan Nie27Weihao Sun28Yi Zhao29Yuan Mao30Po Jiang31Hualiang Ji32Qing Dong33Junming Li34Zhenzhong Li35Xinli Bai36Li Li37Maosong Lin38Ming Dong39Jinxin Li40Ping Zhu41Chan Wang42Yanqiu Zhang43Peng Jiang44Yujue Wang45Rohil Jawed46Jing Xu47Yu Zhang48Qixia Wang49Yue Yang50Fan Yang51Min Lian52Xiang Jiang53Xiao Xiao54Yanmei Li55Jingyuan Fang56Dekai Qiu57Zhen Zhu58Hong Qiu59Jianqiong Zhang60Wenyan Tian61Sufang Chen62Ling Jiang63Bing Ji64Ping Li65Guochang Chen66Tianxue Wu67Yan Sun68Jianjiang Yu69Huijun Tang70Michun He71Min Xia72Hao Pei73Lihua Huang74Zhuye Qing75Jianfang Wu76Qinghai Huang77Junhai Han78Wei Xie79Zhongsheng Sun80Jian Guo81Gengsheng He82M. Eric Gershwin83Zhexiong Lian84Xiang Liu85Michael F. Seldin86Xiangdong Liu87Weichang Chen88Xiong Ma89Key Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Dermatology at No. 1 Hospital, Institute of Dermatology, Anhui Medical UniversityKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Dermatology at No. 1 Hospital, Institute of Dermatology, Anhui Medical UniversityDepartment of Laboratory Medicine, The Fifth People’s Hospital of WuxiDepartment of Laboratory Medicine, The Third People’s Hospital of ZhenjiangDepartment of Laboratory Medicine, The 81th Hospital of PLADepartment of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow UniversityDepartment of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow UniversityDepartment of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow UniversityDepartment of Laboratory Medicine, Subei People’s Hospital, Clinical Medical College, Yangzhou UniversityDepartment of Hepatology, Shuguang Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Laboratory Medicine, Huai’an First People’s Hospital, Nanjing Medical UniversityDepartment of Laboratory Medicine, Jiangyin People’s Hospital, Southeast UniversityDepartment of Laboratory Medicine, The Third People’s Hospital of ChangzhouDepartment of Laboratory Medicine, Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Radiology, The Second Affiliated Hospital of Soochow UniversityDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology, Jiangsu University affiliated Kunshan HospitalDepartment of Gastroenterology, Yixing People’s HospitalDepartment of Gastroenterology, Yancheng First People’s HospitalDepartment of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow UniversityDepartment of Laboratory Medicine, The University Hospital, Southeast UniversityDepartment of Hepatology, The Second Hospital of Nanjing, Southeast UniversityDepartment of Gastroenterology, Taicang First People’s Hospital, Soochow UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Gastroenterology, Eastern Hepatobiliary Surgery HospitalDepartment of Immunology, Nanjing Kingmed Clinical Laboratory Co. Ltd.Department of Hepatology, The Second People’s Hospital of JingjiangDepartment of Gastroenterology, Hai’an People’s Hospital, Nantong University Medical SchoolDepartment of Laboratory Medicine, Suzhou Hospital of Traditional Chinese MedicineDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanchang UniversityDepartment of Paediatrics, The Second Hospital of Hebei Medical UniversityDepartment of Laboratory Medicine, Zhongda Hospital, School of Medicine, Southeast UniversityDepartment of Gastroenterology, Taizhou People’s HospitalDepartment of Hepatology, Traditional Chinese Medicine Hospital of KunshanDepartment of Genomics and Epigenomics, Beijing Institutes of Life Science, Chinese Academy of SciencesDepartment of Gerontology, Beijing HospitalDepartment of Nutrition and Health, School of Public Health, Fudan UniversityDivision of Rheumatology, Allergy, and Clinical Immunology, Rowe Program in Genetics, University of California-DavisDepartment of Immunology, School of Life Sciences, University of Science and Technology of ChinaDepartment of Stomatology, The First Affiliated Hospital, Hainan Medical UniversityKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDepartment of Laboratory Medicine, The Third People’s Hospital of ChangzhouDepartment of Laboratory Medicine, The 81th Hospital of PLAKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityDepartment of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow UniversityDepartment of Laboratory Medicine, The Fifth People’s Hospital of Suzhou, Soochow UniversityDepartment of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow UniversityDepartment of Laboratory Medicine, The 81th Hospital of PLADepartment of Laboratory Medicine, The 81th Hospital of PLADepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of Laboratory Medicine, Subei People’s Hospital, Clinical Medical College, Yangzhou UniversityDepartment of Laboratory Medicine, Subei People’s Hospital, Clinical Medical College, Yangzhou UniversityDepartment of Laboratory Medicine, Jiangyin People’s Hospital, Southeast UniversityDepartment of Laboratory Medicine, Jiangyin People’s Hospital, Southeast UniversityDepartment of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow UniversityDepartment of Laboratory Medicine, Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityDepartment of Laboratory Medicine, The Fifth People’s Hospital of WuxiDepartment of Laboratory Medicine, The Fifth People’s Hospital of WuxiDepartment of Immunology, Nanjing Kingmed Clinical Laboratory Co. Ltd.Department of Hepatology, Traditional Chinese Medicine Hospital of KunshanKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityDepartment of Genomics and Epigenomics, Beijing Institutes of Life Science, Chinese Academy of SciencesDepartment of Gerontology, Beijing HospitalDepartment of Nutrition and Health, School of Public Health, Fudan UniversityDivision of Rheumatology, Allergy, and Clinical Immunology, Rowe Program in Genetics, University of California-DavisDepartment of Immunology, School of Life Sciences, University of Science and Technology of ChinaDepartment of Stomatology, The First Affiliated Hospital, Hainan Medical UniversityDivision of Rheumatology, Allergy, and Clinical Immunology, Rowe Program in Genetics, University of California-DavisKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast UniversityDepartment of Rheumatology, Department of Gastroenterology, The First Affiliated Hospital of Soochow UniversityDepartment of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseasePrimary biliary cholangitis is an autoimmune liver disease. Here, the authors show that variants in interleukin genes which potentially deregulate their expression are associated with this condition, and suggest that the IL21 signalling pathway may have a role in disease aetiology.https://doi.org/10.1038/ncomms14828

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

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