CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases

CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases

CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some stu...

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Main Authors: Xavier Heim, Ahmad Joshkon, Julien Bermudez, Richard Bachelier, Cléa Dubrou, José Boucraut, Alexandrine Foucault-Bertaud, Aurélie S. Leroyer, Francoise Dignat-George, Marcel Blot-Chabaud, Nathalie Bardin
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomedicines
Subjects:
CD146
soluble CD146
inflammation angiogenesis
autoimmunity
Online Access:https://www.mdpi.com/2227-9059/8/12/592
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language English
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author Xavier Heim
Ahmad Joshkon
Julien Bermudez
Richard Bachelier
Cléa Dubrou
José Boucraut
Alexandrine Foucault-Bertaud
Aurélie S. Leroyer
Francoise Dignat-George
Marcel Blot-Chabaud
Nathalie Bardin
spellingShingle Xavier Heim
Ahmad Joshkon
Julien Bermudez
Richard Bachelier
Cléa Dubrou
José Boucraut
Alexandrine Foucault-Bertaud
Aurélie S. Leroyer
Francoise Dignat-George
Marcel Blot-Chabaud
Nathalie Bardin
CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases
Biomedicines
CD146
soluble CD146
inflammation angiogenesis
autoimmunity
author_facet Xavier Heim
Ahmad Joshkon
Julien Bermudez
Richard Bachelier
Cléa Dubrou
José Boucraut
Alexandrine Foucault-Bertaud
Aurélie S. Leroyer
Francoise Dignat-George
Marcel Blot-Chabaud
Nathalie Bardin
author_sort Xavier Heim
title CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases
title_short CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases
title_full CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases
title_fullStr CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases
title_full_unstemmed CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases
title_sort cd146/scd146 in the pathogenesis and monitoring of angiogenic and inflammatory diseases
publisher MDPI AG
series Biomedicines
issn 2227-9059
publishDate 2020-12-01
description CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. In this review, we will focus on how CD146 and sCD146 contribute to the pathogenesis of the aforementioned autoimmune diseases and discuss the relevance of considering it as a biomarker in these pathologies.
topic CD146
soluble CD146
inflammation angiogenesis
autoimmunity
url https://www.mdpi.com/2227-9059/8/12/592
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spelling doaj-2da0476a22c846be9b21fbd4520520712020-12-11T00:03:11ZengMDPI AGBiomedicines2227-90592020-12-01859259210.3390/biomedicines8120592CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory DiseasesXavier Heim0Ahmad Joshkon1Julien Bermudez2Richard Bachelier3Cléa Dubrou4José Boucraut5Alexandrine Foucault-Bertaud6Aurélie S. Leroyer7Francoise Dignat-George8Marcel Blot-Chabaud9Nathalie Bardin10Hematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceService d’immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique Hôpitaux de Marseille (AP-HM), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceHematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L’agriculture, L’alimentation et L’environnement (INRAE), 13005 Marseille, FranceCD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. In this review, we will focus on how CD146 and sCD146 contribute to the pathogenesis of the aforementioned autoimmune diseases and discuss the relevance of considering it as a biomarker in these pathologies.https://www.mdpi.com/2227-9059/8/12/592CD146soluble CD146inflammation angiogenesisautoimmunity

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