Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2

A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) results in one of the strongest genetic traits associated with autoimmune disease outside of the Major Histocompatibility Complex (MHC) genes. However, the consequences of thi...

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Bibliographic Details
Main Authors: Cara Bray, David Wright, Sonja Haupt, Sharyn Thomas, Hans Stauss, Rose Zamoyska
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
PTPN22
CRISPR
Jurkat
T cell signaling
autoimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02595/full

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