Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms
The antimicrobial and antioxidant activities, as well as the DNA-binding of four square-planar Pd(II) complexes, [Pd(terpy)Cl]+ (C1), [Pd(en)Cl2] (C2), [Pd(DMEAImiPr)Cl2] (C3) and [Pd(dach)Cl2] (C4) (terpy = 2,2′:6′,2′′- -terpyridine, en = ethylenediamine, dach = trans-1,2-diaminocyclohexane and DME...
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Serbian Chemical Society
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doaj-2db8a3d0d50f40eeb09d79b3b31109e52020-11-24T23:59:32ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51391820-74212018-01-0183111229124210.2298/JSC180507071R0352-51391800071RAntimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atomsRaković Ivana R.0Radojević Ivana D.1Mladenović Katarina G.2Popovska-Jovičić Biljana D.3Petrović Sara4Čanović Petar P.5Čomić Ljiljana R.6Čanović Predrag S.7Bogojeski Jovana V.8Faculty of Medical Sciences, KragujevacFaculty of Science, KragujevacFaculty of Science, KragujevacFaculty of Medical Sciences, KragujevacFaculty of Medical Sciences, KragujevacFaculty of Medical Sciences, KragujevacFaculty of Science, KragujevacFaculty of Medical Sciences, KragujevacFaculty of Science, KragujevacThe antimicrobial and antioxidant activities, as well as the DNA-binding of four square-planar Pd(II) complexes, [Pd(terpy)Cl]+ (C1), [Pd(en)Cl2] (C2), [Pd(DMEAImiPr)Cl2] (C3) and [Pd(dach)Cl2] (C4) (terpy = 2,2′:6′,2′′- -terpyridine, en = ethylenediamine, dach = trans-1,2-diaminocyclohexane and DMEAImiPr = N2-((1,3-dihydro-1,3-diisopropyl-4,5-dimethyl)-2H-imidazol-2- ylidene)-N1,N1-dimethyl-1,2-ethanediamine are reported. The antimicrobial activities of the Pd(II) complexes with the appropriate ligands were tested using the microdilution method against 18 strains of microorganisms, whereby the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) were determined. The antibiofilm activity of [Pd(terpy)Cl]+ and the corresponding ligand were determined on a formed biofilm. The intensity of antimicrobial activity varied depending on the type of microorganism and the tested compound. The C1 complex with the corresponding ligand demonstrated significantly greater overall antimicrobial activity than C2, C3 and C4. The antibacterial activity of the C1 complex was better than its antifungal activity that was overall greater than that of the positive control, fluconazole. The greatest sensitivity for C1 and L1 was with Penicillium italicum (MIC < 0.49 μg mL-1) among the fungi, and with Proteus mirabilis ATCC 12453 (MIC = 0.98 μg mL-1) among the tested bacteria. The tested compounds show low and moderate antibiofilm activity. The complexes showed weak antioxidant properties when tested using the DPPH (1,1-diphenyl-2- -picrylhydrazyl) method. The interaction of the metal complexes C1–C4 with calf thymus DNA (CT-DNA) was further examined by absorption (UV–Vis) and emission spectral studies (EthBr displacement studies). Overall, the investigated complexes exhibited good DNA interaction ability. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172011 and Grant no. 173032]http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800071R.pdfpalladium(II) complexesbiological activitystructurereactivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raković Ivana R. Radojević Ivana D. Mladenović Katarina G. Popovska-Jovičić Biljana D. Petrović Sara Čanović Petar P. Čomić Ljiljana R. Čanović Predrag S. Bogojeski Jovana V. |
spellingShingle |
Raković Ivana R. Radojević Ivana D. Mladenović Katarina G. Popovska-Jovičić Biljana D. Petrović Sara Čanović Petar P. Čomić Ljiljana R. Čanović Predrag S. Bogojeski Jovana V. Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms Journal of the Serbian Chemical Society palladium(II) complexes biological activity structure reactivity |
author_facet |
Raković Ivana R. Radojević Ivana D. Mladenović Katarina G. Popovska-Jovičić Biljana D. Petrović Sara Čanović Petar P. Čomić Ljiljana R. Čanović Predrag S. Bogojeski Jovana V. |
author_sort |
Raković Ivana R. |
title |
Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms |
title_short |
Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms |
title_full |
Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms |
title_fullStr |
Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms |
title_full_unstemmed |
Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms |
title_sort |
antimicrobial, antioxidant and dna-binding studies of palladium(ii) complexes with different chelate ligands containing nitrogen donor atoms |
publisher |
Serbian Chemical Society |
series |
Journal of the Serbian Chemical Society |
issn |
0352-5139 1820-7421 |
publishDate |
2018-01-01 |
description |
The antimicrobial and antioxidant activities, as well as the DNA-binding of four square-planar Pd(II) complexes, [Pd(terpy)Cl]+ (C1), [Pd(en)Cl2] (C2), [Pd(DMEAImiPr)Cl2] (C3) and [Pd(dach)Cl2] (C4) (terpy = 2,2′:6′,2′′- -terpyridine, en = ethylenediamine, dach = trans-1,2-diaminocyclohexane and DMEAImiPr = N2-((1,3-dihydro-1,3-diisopropyl-4,5-dimethyl)-2H-imidazol-2- ylidene)-N1,N1-dimethyl-1,2-ethanediamine are reported. The antimicrobial activities of the Pd(II) complexes with the appropriate ligands were tested using the microdilution method against 18 strains of microorganisms, whereby the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) were determined. The antibiofilm activity of [Pd(terpy)Cl]+ and the corresponding ligand were determined on a formed biofilm. The intensity of antimicrobial activity varied depending on the type of microorganism and the tested compound. The C1 complex with the corresponding ligand demonstrated significantly greater overall antimicrobial activity than C2, C3 and C4. The antibacterial activity of the C1 complex was better than its antifungal activity that was overall greater than that of the positive control, fluconazole. The greatest sensitivity for C1 and L1 was with Penicillium italicum (MIC < 0.49 μg mL-1) among the fungi, and with Proteus mirabilis ATCC 12453 (MIC = 0.98 μg mL-1) among the tested bacteria. The tested compounds show low and moderate antibiofilm activity. The complexes showed weak antioxidant properties when tested using the DPPH (1,1-diphenyl-2- -picrylhydrazyl) method. The interaction of the metal complexes C1–C4 with calf thymus DNA (CT-DNA) was further examined by absorption (UV–Vis) and emission spectral studies (EthBr displacement studies). Overall, the investigated complexes exhibited good DNA interaction ability. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172011 and Grant no. 173032] |
topic |
palladium(II) complexes biological activity structure reactivity |
url |
http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800071R.pdf |
work_keys_str_mv |
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