A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver Disease
Mitochondria are organelles that are essential for cellular homeostasis including energy harvesting through oxidative phosphorylation. Mitochondrial dysfunction plays a vital role in liver diseases as it produces a large amount of reactive oxygen species (ROS), in turn leading to further oxidative d...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2020-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2020/5835910 |
id |
doaj-2db8ae1c155d40e4bd0a09b00364d014 |
---|---|
record_format |
Article |
spelling |
doaj-2db8ae1c155d40e4bd0a09b00364d0142020-11-30T09:11:29ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942020-01-01202010.1155/2020/58359105835910A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver DiseaseWei Xuan0Dandan Song1Youyou Yan2Ming Yang3Yan Sun4Department of Hepatopancreaticobiliary Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, ChinaDepartment of Clinical Laboratory, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, ChinaDepartment of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, ChinaDepartment of Molecular Biology, College of Basic Medical Sciences, No. 126 Xinmin Street, Changchun 130041, ChinaDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, ChinaMitochondria are organelles that are essential for cellular homeostasis including energy harvesting through oxidative phosphorylation. Mitochondrial dysfunction plays a vital role in liver diseases as it produces a large amount of reactive oxygen species (ROS), in turn leading to further oxidative damage to the structure and function of mitochondria and other cellular components. More severe oxidative damage occurred in mitochondrial DNA (mtDNA) than in nuclear DNA. mtDNA dysfunction results in further oxidative damage as it participates in encoding respiratory chain polypeptides. In addition, mtDNA can leave the mitochondria and enter the cytoplasm and extracellular environment. mtDNA is derived from ancient bacteria, contains many unmethylated CpG dinucleotide repeats similar to bacterial DNA, and thus can induce inflammation to exacerbate damage to liver cells and distal organs by activating toll-like receptor 9, inflammatory bodies, and stimulator of interferon genes (STING). In this review, we focus on the mechanism by which mtDNA alterations cause liver injuries, including nonalcoholic fatty liver, alcoholic liver disease, drug-induced liver injury, viral hepatitis, and liver cancer.http://dx.doi.org/10.1155/2020/5835910 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Xuan Dandan Song Youyou Yan Ming Yang Yan Sun |
spellingShingle |
Wei Xuan Dandan Song Youyou Yan Ming Yang Yan Sun A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver Disease Oxidative Medicine and Cellular Longevity |
author_facet |
Wei Xuan Dandan Song Youyou Yan Ming Yang Yan Sun |
author_sort |
Wei Xuan |
title |
A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver Disease |
title_short |
A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver Disease |
title_full |
A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver Disease |
title_fullStr |
A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver Disease |
title_full_unstemmed |
A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver Disease |
title_sort |
potential role for mitochondrial dna in the activation of oxidative stress and inflammation in liver disease |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2020-01-01 |
description |
Mitochondria are organelles that are essential for cellular homeostasis including energy harvesting through oxidative phosphorylation. Mitochondrial dysfunction plays a vital role in liver diseases as it produces a large amount of reactive oxygen species (ROS), in turn leading to further oxidative damage to the structure and function of mitochondria and other cellular components. More severe oxidative damage occurred in mitochondrial DNA (mtDNA) than in nuclear DNA. mtDNA dysfunction results in further oxidative damage as it participates in encoding respiratory chain polypeptides. In addition, mtDNA can leave the mitochondria and enter the cytoplasm and extracellular environment. mtDNA is derived from ancient bacteria, contains many unmethylated CpG dinucleotide repeats similar to bacterial DNA, and thus can induce inflammation to exacerbate damage to liver cells and distal organs by activating toll-like receptor 9, inflammatory bodies, and stimulator of interferon genes (STING). In this review, we focus on the mechanism by which mtDNA alterations cause liver injuries, including nonalcoholic fatty liver, alcoholic liver disease, drug-induced liver injury, viral hepatitis, and liver cancer. |
url |
http://dx.doi.org/10.1155/2020/5835910 |
work_keys_str_mv |
AT weixuan apotentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT dandansong apotentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT youyouyan apotentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT mingyang apotentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT yansun apotentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT weixuan potentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT dandansong potentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT youyouyan potentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT mingyang potentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease AT yansun potentialroleformitochondrialdnaintheactivationofoxidativestressandinflammationinliverdisease |
_version_ |
1715027776813137920 |