Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review
Abstract Background Primary hyperoxaluria (PH) is a rare inborn disorder of the metabolism of glyoxylate, which causes the hallmark production oxalate and forms insoluble calcium oxalate crystals that accumulate in the kidney and other organs. Since the manifestation of PH varies from recurrent neph...
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doaj-2dba2769d63542628d3ad7342834b28c2020-11-25T03:08:06ZengBMCBMC Nephrology1471-23692019-06-0120111110.1186/s12882-019-1402-2Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature reviewRuiming Cai0Minzhuang Lin1Zhiyong Chen2Yongtong Lai3Xianen Huang4Guozhi Zhao5Xuekun Guo6Zhongtang Xiong7Juan Chen8Hui Chen9Qingping Jiang10Shaoyan Liu11Yuexin Yang12Weixiang Liang13Minhui Zou14Tao Liu15Wenfang Chen16Hongzhou Liu17Juan Peng18Department of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Organ Transplantation, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Ultrasound, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Ultrasound, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Ultrasound, The Third Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pathology, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Clinical Laboratory, Guangzhou Kingmed Center for Clinical Laboratory Co., LtdDepartment of Pathology, The Third Affiliated Hospital of Guangzhou Medical UniversityAbstract Background Primary hyperoxaluria (PH) is a rare inborn disorder of the metabolism of glyoxylate, which causes the hallmark production oxalate and forms insoluble calcium oxalate crystals that accumulate in the kidney and other organs. Since the manifestation of PH varies from recurrent nephrolithiasis, nephrocalcinosis, and end-stage renal disease with age at onset of symptoms ranging from infancy to the sixth decade, the disease remains undiagnosed until after kidney transplantation in some cases. Case presentation Herein, we report 3 cases of PH diagnosed after kidney transplantation failure, providing the comprehensive clinical course, the ultrasonic image of renal graft and pathologic image of the biopsy, highlighting the relevance of biopsy findings and the results of molecular genetic testing. We also focus on the treatment and the unfavorable outcome of the patients. Meanwhile, we review the literature and show the additional 10 reported cases of PH diagnosed after kidney transplantation. Additionally, we discuss the progressive molecular understanding of the mechanisms involved in PH and molecular therapy. Conclusions Overall, the necessity of preoperative screening of PH in all patients even with a minor history of nephrolithiasis and the importance of proper treatment are the lessons we learn from the 3 cases, which prompt us to avoid tragedies.http://link.springer.com/article/10.1186/s12882-019-1402-2Primary hyperoxaluriaKidney transplantation failureCalcium oxalate crystalsCase report |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruiming Cai Minzhuang Lin Zhiyong Chen Yongtong Lai Xianen Huang Guozhi Zhao Xuekun Guo Zhongtang Xiong Juan Chen Hui Chen Qingping Jiang Shaoyan Liu Yuexin Yang Weixiang Liang Minhui Zou Tao Liu Wenfang Chen Hongzhou Liu Juan Peng |
spellingShingle |
Ruiming Cai Minzhuang Lin Zhiyong Chen Yongtong Lai Xianen Huang Guozhi Zhao Xuekun Guo Zhongtang Xiong Juan Chen Hui Chen Qingping Jiang Shaoyan Liu Yuexin Yang Weixiang Liang Minhui Zou Tao Liu Wenfang Chen Hongzhou Liu Juan Peng Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review BMC Nephrology Primary hyperoxaluria Kidney transplantation failure Calcium oxalate crystals Case report |
author_facet |
Ruiming Cai Minzhuang Lin Zhiyong Chen Yongtong Lai Xianen Huang Guozhi Zhao Xuekun Guo Zhongtang Xiong Juan Chen Hui Chen Qingping Jiang Shaoyan Liu Yuexin Yang Weixiang Liang Minhui Zou Tao Liu Wenfang Chen Hongzhou Liu Juan Peng |
author_sort |
Ruiming Cai |
title |
Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review |
title_short |
Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review |
title_full |
Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review |
title_fullStr |
Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review |
title_full_unstemmed |
Primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review |
title_sort |
primary hyperoxaluria diagnosed after kidney transplantation failure: lesson from 3 case reports and literature review |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2019-06-01 |
description |
Abstract Background Primary hyperoxaluria (PH) is a rare inborn disorder of the metabolism of glyoxylate, which causes the hallmark production oxalate and forms insoluble calcium oxalate crystals that accumulate in the kidney and other organs. Since the manifestation of PH varies from recurrent nephrolithiasis, nephrocalcinosis, and end-stage renal disease with age at onset of symptoms ranging from infancy to the sixth decade, the disease remains undiagnosed until after kidney transplantation in some cases. Case presentation Herein, we report 3 cases of PH diagnosed after kidney transplantation failure, providing the comprehensive clinical course, the ultrasonic image of renal graft and pathologic image of the biopsy, highlighting the relevance of biopsy findings and the results of molecular genetic testing. We also focus on the treatment and the unfavorable outcome of the patients. Meanwhile, we review the literature and show the additional 10 reported cases of PH diagnosed after kidney transplantation. Additionally, we discuss the progressive molecular understanding of the mechanisms involved in PH and molecular therapy. Conclusions Overall, the necessity of preoperative screening of PH in all patients even with a minor history of nephrolithiasis and the importance of proper treatment are the lessons we learn from the 3 cases, which prompt us to avoid tragedies. |
topic |
Primary hyperoxaluria Kidney transplantation failure Calcium oxalate crystals Case report |
url |
http://link.springer.com/article/10.1186/s12882-019-1402-2 |
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