Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, whic...
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2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12475 |
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doaj-2dbbe918315649bd816bccb6c1b9c78c2021-05-11T11:00:47ZengNature Publishing GroupNature Communications2041-17232016-08-017111310.1038/ncomms12475Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemiaPierre Hirsch0Yanyan Zhang1Ruoping Tang2Virginie Joulin3Hélène Boutroux4Elodie Pronier5Hannah Moatti6Pascale Flandrin7Christophe Marzac8Dominique Bories9Fanny Fava10Hayat Mokrani11Aline Betems12Florence Lorre13Rémi Favier14Frédéric Féger15Mohamad Mohty16Luc Douay17Ollivier Legrand18Chrystèle Bilhou-Nabera19Fawzia Louache20François Delhommeau21Sorbonne Universités, UPMC Univ Paris 06Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 1170AP-HP, Hôpital St Antoine, Service d'Hématologie clinique et de thérapie cellulaireInstitut National de la Santé et de la Recherche Médicale (INSERM), UMRS 1170Sorbonne Universités, UPMC Univ Paris 06Institut Gustave Roussy, Univ Paris-Sud, Université Paris SaclaySorbonne Universités, UPMC Univ Paris 06Sorbonne Universités, UPMC Univ Paris 06AP-HP, Hôpital Saint-Antoine & Hôpital Armand-Trousseau, Service d’hématologie biologiqueAP-HP, Hôpital Henri Mondor, Unité d'Hématologie MoléculaireSorbonne Universités, UPMC Univ Paris 06Institut Gustave Roussy, Univ Paris-Sud, Université Paris SaclayInstitut Gustave Roussy, Univ Paris-Sud, Université Paris SaclayAP-HP, Hôpital Saint-Antoine, Laboratoire commun de biologie et génétique moléculairesAP-HP, Hôpital Saint-Antoine & Hôpital Armand-Trousseau, Service d’hématologie biologiqueAP-HP, Hôpital Saint-Antoine & Hôpital Armand-Trousseau, Service d’hématologie biologiqueSorbonne Universités, UPMC Univ Paris 06Sorbonne Universités, UPMC Univ Paris 06Sorbonne Universités, UPMC Univ Paris 06Sorbonne Universités, UPMC Univ Paris 06Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 1170Sorbonne Universités, UPMC Univ Paris 06Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, which can be used to track evolution of the disease.https://doi.org/10.1038/ncomms12475 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Pierre Hirsch Yanyan Zhang Ruoping Tang Virginie Joulin Hélène Boutroux Elodie Pronier Hannah Moatti Pascale Flandrin Christophe Marzac Dominique Bories Fanny Fava Hayat Mokrani Aline Betems Florence Lorre Rémi Favier Frédéric Féger Mohamad Mohty Luc Douay Ollivier Legrand Chrystèle Bilhou-Nabera Fawzia Louache François Delhommeau |
| spellingShingle |
Pierre Hirsch Yanyan Zhang Ruoping Tang Virginie Joulin Hélène Boutroux Elodie Pronier Hannah Moatti Pascale Flandrin Christophe Marzac Dominique Bories Fanny Fava Hayat Mokrani Aline Betems Florence Lorre Rémi Favier Frédéric Féger Mohamad Mohty Luc Douay Ollivier Legrand Chrystèle Bilhou-Nabera Fawzia Louache François Delhommeau Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia Nature Communications |
| author_facet |
Pierre Hirsch Yanyan Zhang Ruoping Tang Virginie Joulin Hélène Boutroux Elodie Pronier Hannah Moatti Pascale Flandrin Christophe Marzac Dominique Bories Fanny Fava Hayat Mokrani Aline Betems Florence Lorre Rémi Favier Frédéric Féger Mohamad Mohty Luc Douay Ollivier Legrand Chrystèle Bilhou-Nabera Fawzia Louache François Delhommeau |
| author_sort |
Pierre Hirsch |
| title |
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia |
| title_short |
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia |
| title_full |
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia |
| title_fullStr |
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia |
| title_full_unstemmed |
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia |
| title_sort |
genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-08-01 |
| description |
Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, which can be used to track evolution of the disease. |
| url |
https://doi.org/10.1038/ncomms12475 |
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