An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action
Transdermal drug delivery has attracted considerable attention over the past 2-3 decades in regard of its many potentialadvantages. However, the role of the skin as a protective barrier renders skin absorption of most drugs problematic. Therefore,skin penetration enhancers are frequently used in the...
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Prince of Songkla University
2009-08-01
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Series: | Songklanakarin Journal of Science and Technology (SJST) |
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Online Access: | http://www.rdoapp.psu.ac.th/html/sjst/journal/31-3/0125-3395-31-3-299-321.pdf |
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doaj-2dc36664da87495fbb028ef335e9d3c42020-11-24T22:08:15ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952009-08-01313299321An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of actionSarunyoo SongkroTransdermal drug delivery has attracted considerable attention over the past 2-3 decades in regard of its many potentialadvantages. However, the role of the skin as a protective barrier renders skin absorption of most drugs problematic. Therefore,skin penetration enhancers are frequently used in the field of transdermal drug delivery in order to reversibly reduce thebarrier function of the stratum corneum, the outermost layer of the skin. To date, a wide range of chemical compounds havebeen shown to enhance the skin penetration of therapeutic drugs. This review presents a critical account of the most commonlyused chemical penetration enhancers (fatty acids and surfactants), and some newer classes of chemical enhancers (terpenes,polymers, monoolein, oxazolidinones), with emphasis on their efficacy, mechanism of action, and skin irritation potential. Thisreview also discusses the traditional and more recently developed methods for the screening and evaluation of chemical penetration enhancers, and addresses the continuing problems in the rational selection of a chemical penetration enhancer for a specific drug to be delivered via the transdermal route.http://www.rdoapp.psu.ac.th/html/sjst/journal/31-3/0125-3395-31-3-299-321.pdfskin penetration enhancerstratum corneummechanism of actionskin irritation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarunyoo Songkro |
spellingShingle |
Sarunyoo Songkro An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action Songklanakarin Journal of Science and Technology (SJST) skin penetration enhancer stratum corneum mechanism of action skin irritation |
author_facet |
Sarunyoo Songkro |
author_sort |
Sarunyoo Songkro |
title |
An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action |
title_short |
An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action |
title_full |
An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action |
title_fullStr |
An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action |
title_full_unstemmed |
An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action |
title_sort |
overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action |
publisher |
Prince of Songkla University |
series |
Songklanakarin Journal of Science and Technology (SJST) |
issn |
0125-3395 |
publishDate |
2009-08-01 |
description |
Transdermal drug delivery has attracted considerable attention over the past 2-3 decades in regard of its many potentialadvantages. However, the role of the skin as a protective barrier renders skin absorption of most drugs problematic. Therefore,skin penetration enhancers are frequently used in the field of transdermal drug delivery in order to reversibly reduce thebarrier function of the stratum corneum, the outermost layer of the skin. To date, a wide range of chemical compounds havebeen shown to enhance the skin penetration of therapeutic drugs. This review presents a critical account of the most commonlyused chemical penetration enhancers (fatty acids and surfactants), and some newer classes of chemical enhancers (terpenes,polymers, monoolein, oxazolidinones), with emphasis on their efficacy, mechanism of action, and skin irritation potential. Thisreview also discusses the traditional and more recently developed methods for the screening and evaluation of chemical penetration enhancers, and addresses the continuing problems in the rational selection of a chemical penetration enhancer for a specific drug to be delivered via the transdermal route. |
topic |
skin penetration enhancer stratum corneum mechanism of action skin irritation |
url |
http://www.rdoapp.psu.ac.th/html/sjst/journal/31-3/0125-3395-31-3-299-321.pdf |
work_keys_str_mv |
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