Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice
Cinnamomum osmophloeum ct. linalool (土肉桂 tǔ ròu guì) is one chemotype of the indigenous cinnamons in Taiwan. This study examined the anxiolytic potency of leaf essential oil (LEO) from C. osmophloeum ct. linalool and its main constituent on 4-week ICR mice using an open field test (OFT), a light–dar...
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doaj-2dc3b0f7777b42e282d11d65b5778cb02020-11-24T23:13:56ZengElsevierJournal of Traditional and Complementary Medicine2225-41102015-01-0151273410.1016/j.jtcme.2014.10.007Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in miceBing-Ho Cheng0Lee-Yan Sheen1Shang-Tzen Chang2School of Forest and Resource Conservation, National Taiwan University, Taipei, TaiwanInstitute of Food Science and Technology, National Taiwan University, Taipei, TaiwanSchool of Forest and Resource Conservation, National Taiwan University, Taipei, TaiwanCinnamomum osmophloeum ct. linalool (土肉桂 tǔ ròu guì) is one chemotype of the indigenous cinnamons in Taiwan. This study examined the anxiolytic potency of leaf essential oil (LEO) from C. osmophloeum ct. linalool and its main constituent on 4-week ICR mice using an open field test (OFT), a light–dark test (LDT) and an elevated plus maze test (EPT). After oral administration of corn oil, LEO (250 mg/kg and 500 mg/kg), S-(+)-linalool (500 mg/kg), R-(−)-linalool (500 mg/kg), and trazodone hydrochloride (75 mg/kg) for 14 days, the anxiolytic effects on mice behavior were evaluated. The results showed that LEO from C. osmophloeum ct. linalool leaves and S-(+)-linalool can significantly increase the time mice remained in the center area of the OFT, the illuminated area of the LDT and the open arms of the EPT without any side effects affecting motor activity, indicating excellent anxiolytic responses. Furthermore, results from the measurements of monoamines in mice brain revealed decreases in serotonin, dopamine, and norepinephrine, which are consistent with their anxiolytic effects in animal models. The findings obtained suggest that LEO from C. osmophloeum ct. linalool and its major compound, S-(+)-linalool, possess anxiolytic properties without any side effects and thus support their potential use in treatment of anxiety disorders.http://www.sciencedirect.com/science/article/pii/S222541101400008Xanxiolytic activityCinnamomum osmophloeum ct. linaloolleaf essential oilS-(+)-linaloolmonoamines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bing-Ho Cheng Lee-Yan Sheen Shang-Tzen Chang |
spellingShingle |
Bing-Ho Cheng Lee-Yan Sheen Shang-Tzen Chang Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice Journal of Traditional and Complementary Medicine anxiolytic activity Cinnamomum osmophloeum ct. linalool leaf essential oil S-(+)-linalool monoamines |
author_facet |
Bing-Ho Cheng Lee-Yan Sheen Shang-Tzen Chang |
author_sort |
Bing-Ho Cheng |
title |
Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice |
title_short |
Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice |
title_full |
Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice |
title_fullStr |
Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice |
title_full_unstemmed |
Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice |
title_sort |
evaluation of anxiolytic potency of essential oil and s-(+)-linalool from cinnamomum osmophloeum ct. linalool leaves in mice |
publisher |
Elsevier |
series |
Journal of Traditional and Complementary Medicine |
issn |
2225-4110 |
publishDate |
2015-01-01 |
description |
Cinnamomum osmophloeum ct. linalool (土肉桂 tǔ ròu guì) is one chemotype of the indigenous cinnamons in Taiwan. This study examined the anxiolytic potency of leaf essential oil (LEO) from C. osmophloeum ct. linalool and its main constituent on 4-week ICR mice using an open field test (OFT), a light–dark test (LDT) and an elevated plus maze test (EPT). After oral administration of corn oil, LEO (250 mg/kg and 500 mg/kg), S-(+)-linalool (500 mg/kg), R-(−)-linalool (500 mg/kg), and trazodone hydrochloride (75 mg/kg) for 14 days, the anxiolytic effects on mice behavior were evaluated. The results showed that LEO from C. osmophloeum ct. linalool leaves and S-(+)-linalool can significantly increase the time mice remained in the center area of the OFT, the illuminated area of the LDT and the open arms of the EPT without any side effects affecting motor activity, indicating excellent anxiolytic responses. Furthermore, results from the measurements of monoamines in mice brain revealed decreases in serotonin, dopamine, and norepinephrine, which are consistent with their anxiolytic effects in animal models. The findings obtained suggest that LEO from C. osmophloeum ct. linalool and its major compound, S-(+)-linalool, possess anxiolytic properties without any side effects and thus support their potential use in treatment of anxiety disorders. |
topic |
anxiolytic activity Cinnamomum osmophloeum ct. linalool leaf essential oil S-(+)-linalool monoamines |
url |
http://www.sciencedirect.com/science/article/pii/S222541101400008X |
work_keys_str_mv |
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