Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study
Abstract Background Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often coexist. Moreover, elderly patients suffering from HF have a higher incidence of COPD, which further complicates their clinical condition. Indacaterol/glycopirronium has shown benefits in the treatment of C...
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doaj-2dc6e45c3d44432bbbd496cebc0f82762020-11-25T03:35:31ZengBMCBMC Cardiovascular Disorders1471-22612019-01-011911710.1186/s12872-018-0986-yMorbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational studyEugenio Roberto Cosentino0Matteo Landolfo1Crescenzio Bentivenga2Luca Spinardi3Daniela Degli Esposti4Arrigo Francesco Cicero5Rinaldo Miceli6Virna Bui7Emanuela Berardi8Claudio Borghi9Cardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaCardiology Department, Hospital S. ValentinoCardio–Thoracic–Vascular Department, Policlinico S. Orsola-Malpighi, Università di BolognaAbstract Background Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often coexist. Moreover, elderly patients suffering from HF have a higher incidence of COPD, which further complicates their clinical condition. Indacaterol/glycopirronium has shown benefits in the treatment of COPD, with few cardiologic adverse effects. We evaluated the safety and efficacy of this therapy in patients with history of HF. Methods We enrolled 56 patients with a history of HF (New York Heart Association [NYHA] classes II and III) and stable COPD. We evaluated blood samples, clinical assessment, echocardiograms and basal spirometry at baseline and after 6 months of therapy with indacaterol/glycopirronium. In addition, the number of re-hospitalizations during the treatment period was evaluated. Results The treatment was well tolerated. Brain natriuretic peptide (BNP) levels were significantly reduced compared with baseline (p < 0.001) after 6 months of treatment, and a higher percentage of patients improved their clinical status compared with baseline (p < 0.001). Minor changes were noted in the hemodynamic and metabolic parameters. Significant improvements in the echocardiographic parameters were noted in HF with reduced ejection fraction (HFrEF) patients. All respiratory parameters (forced expiratory volume in 1 s [FEV1], FEV1/forced vital capacity [FVC] ratio and COPD Assessment Test [CAT] scores) improved significantly (p < 0.001). No hospitalizations owing to HF or COPD exacerbation occurred. One patient died of respiratory failure. Conclusion Indacaterol/glycopirronium was well-tolerated and effective in the treatment of COPD in this cohort of patients with a history of HF. Further studies are needed to clarify whether this compound can have a direct role in improving overall cardiovascular function.http://link.springer.com/article/10.1186/s12872-018-0986-yChronic obstructive pulmonary diseaseElderlyHeart failureIndacaterol/glycopirronium |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eugenio Roberto Cosentino Matteo Landolfo Crescenzio Bentivenga Luca Spinardi Daniela Degli Esposti Arrigo Francesco Cicero Rinaldo Miceli Virna Bui Emanuela Berardi Claudio Borghi |
spellingShingle |
Eugenio Roberto Cosentino Matteo Landolfo Crescenzio Bentivenga Luca Spinardi Daniela Degli Esposti Arrigo Francesco Cicero Rinaldo Miceli Virna Bui Emanuela Berardi Claudio Borghi Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study BMC Cardiovascular Disorders Chronic obstructive pulmonary disease Elderly Heart failure Indacaterol/glycopirronium |
author_facet |
Eugenio Roberto Cosentino Matteo Landolfo Crescenzio Bentivenga Luca Spinardi Daniela Degli Esposti Arrigo Francesco Cicero Rinaldo Miceli Virna Bui Emanuela Berardi Claudio Borghi |
author_sort |
Eugenio Roberto Cosentino |
title |
Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study |
title_short |
Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study |
title_full |
Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study |
title_fullStr |
Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study |
title_full_unstemmed |
Morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study |
title_sort |
morbidity and mortality in a population of patients affected by heart failure and chronic obstructive pulmonary disease: an observational study |
publisher |
BMC |
series |
BMC Cardiovascular Disorders |
issn |
1471-2261 |
publishDate |
2019-01-01 |
description |
Abstract Background Chronic obstructive pulmonary disease (COPD) and heart failure (HF) often coexist. Moreover, elderly patients suffering from HF have a higher incidence of COPD, which further complicates their clinical condition. Indacaterol/glycopirronium has shown benefits in the treatment of COPD, with few cardiologic adverse effects. We evaluated the safety and efficacy of this therapy in patients with history of HF. Methods We enrolled 56 patients with a history of HF (New York Heart Association [NYHA] classes II and III) and stable COPD. We evaluated blood samples, clinical assessment, echocardiograms and basal spirometry at baseline and after 6 months of therapy with indacaterol/glycopirronium. In addition, the number of re-hospitalizations during the treatment period was evaluated. Results The treatment was well tolerated. Brain natriuretic peptide (BNP) levels were significantly reduced compared with baseline (p < 0.001) after 6 months of treatment, and a higher percentage of patients improved their clinical status compared with baseline (p < 0.001). Minor changes were noted in the hemodynamic and metabolic parameters. Significant improvements in the echocardiographic parameters were noted in HF with reduced ejection fraction (HFrEF) patients. All respiratory parameters (forced expiratory volume in 1 s [FEV1], FEV1/forced vital capacity [FVC] ratio and COPD Assessment Test [CAT] scores) improved significantly (p < 0.001). No hospitalizations owing to HF or COPD exacerbation occurred. One patient died of respiratory failure. Conclusion Indacaterol/glycopirronium was well-tolerated and effective in the treatment of COPD in this cohort of patients with a history of HF. Further studies are needed to clarify whether this compound can have a direct role in improving overall cardiovascular function. |
topic |
Chronic obstructive pulmonary disease Elderly Heart failure Indacaterol/glycopirronium |
url |
http://link.springer.com/article/10.1186/s12872-018-0986-y |
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