Collaborative Medication Reviews to Identify Inappropriate Prescribing in Pre-Admission Medications at Emergency Department Short-Term Ward

• Main Authors: Celikkayalar E, Puustinen J, Palmgren J, Airaksinen M
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-04-01
• Series: Integrated Pharmacy Research and Practice
• Subjects: medication reviews; collaborative medication reviews; inappropriate prescribing; potentially inappropriate medications; emergency department; clinical pharmacist
• Online Access: https://www.dovepress.com/collaborative-medication-reviews-to-identify-inappropriate-prescribing-peer-reviewed-fulltext-article-IPRP

Ercan Celikkayalar,1,2 Juha Puustinen,1,3,4 Joni Palmgren,2 Marja Airaksinen1 1Clinical Pharmacy Group, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; 2Hospital Pharmacy Department, Satasairaala Central Hospital, Pori, Finland; 3Social Security Center of Pori, Pori, Finland; 4Unit of Neurology, Satasairaala Central Hospital, Pori, FinlandCorrespondence: Ercan Celikkayalar Email [e-mail]: Collaborative medication reviews (CMR) have been shown to reduce inappropriate prescribing (IP) in various settings. This study aimed at describing a CMR practice in an emergency department (ED) short-term ward in Finland to investigate IP in pre-admission medications.Patients and Methods: Pre-admission medications were collaboratively reviewed for all the adult ED admissions within a 5-month study period in 2016. Types of IP were inductively categorized, and descriptive statistics were used to show the incidence and type of IP events.Results: The pre-admission medications of 855 adult ED patients were reviewed by the pharmacist, with 113 IP events identified in 83 (9.7%) of the patients. The majority (81%, n=67) of these patients were older adults (≥ 65 years). Of these 94 IP events identified in 67 older patients, 58 (62%) were confirmed by the ED physicians. The following 3 main categories were inductively developed for the types of identified and confirmed IP events: 1) Misprescribing (prescription of medications that significantly increase the risk of adverse drug events); 2) Overprescribing (prescription of medications for which no clear clinical indications exist); and 3) Underprescribing (omission of potentially beneficial medications that are clinically indicated for treatment or prevention of a disease). Misprescribing was the most common type of IP identified (79% of the identified and 72% confirmed IP events). Benzodiazepines (29%) and antidepressants (28%) were involved in 33 out of 58 (57%) confirmed IP events. Medications with strong anticholinergic effects were involved in 19% of the confirmed IP events.Conclusion: The CMR practice was able to identify IP in pre-admission medications of about one-tenth of ED patients. Older patients using benzodiazepines and drugs with strong anticholinergic effects should be paid special attention to ED admissions.Keywords: medication reviews, collaborative medication reviews, inappropriate prescribing, potentially inappropriate medications, emergency department, clinical pharmacist