| Summary: | Introduction: Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors. The specificity of each component of metabolic syndrome improves its management.
Objective: Do patients with MetS have arterial modifications? Which MetS components are they most closely linked to?
Materials and methods: Our population recorded 348 patients (185 men and 163 women). These patients entered the day hospital in order to have a cardiovascular check-up. We measured brachial and central blood pressure, augmentation index, and pulse wave velocity (PWV).
Results: 150 patients did have a metabolic syndrome (MetS+) and 198 did not (MetS-). PWV is higher in MetS+ patients, but it does not sustain after adjustment with confounding factors. Within this population, 93 have diabetes mellitus and multiple parameter correlation of PWV with each of MetS components in this population show a significant association with glucose metabolism impairment only.
MetS+
no diabetes
diabetes
p
(n=150)
(n=57)
(n=93)
PWV (m/s)
13.74±3.66
12.71±3.49
14.35±3.65
0.0027
PWV (m/s) (*)
12.94±3.06
14.11±2.99
0.0259
PWV (m/s) (*) & MetS_HDL
12.96±3.15
14.15±3.02
0.0261
PWV (m/s) (*) & MetS_WC
13.07±3.50
14.22±3.55
0.0283
PWV (m/s) (*) & MetS_TG
12.96±3.07
14.08±3.11
0.0371
PWV (m/s) (*) & MetS_HTA
13.79±11.34
15.00±15.06
0.0227
PWV (m/s) (*) & MetS_Glyc
12.93±3.07
13.88±4.98
0.1484
Conclusion:
MetS+ patients have a higher PWV than MetS- patients but this difference disappears after adjustment to classic factors.
Diabetic patients have a significantly higher PWV even after adjustment.
When performing multiple parameter relationship with different components of MetS, we find that only glucose metabolism impairment is independently and positively correlated to PWV.
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