P3.02 GLUCOSE METABOLISM IMPAIRMENT IN METABOLIC SYNDROME IS LINKED WITH INCREASED PULSE WAVE VELOCITY

• Main Authors: A.L. Lieber, C. Vesin, M.E. Safar, B.I. Levy, J. Blacher
• Format: Article
• Language: English
• Published: Atlantis Press 2009-12-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125927292/view

Introduction: Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors. The specificity of each component of metabolic syndrome improves its management. Objective: Do patients with MetS have arterial modifications? Which MetS components are they most closely linked to? Materials and methods: Our population recorded 348 patients (185 men and 163 women). These patients entered the day hospital in order to have a cardiovascular check-up. We measured brachial and central blood pressure, augmentation index, and pulse wave velocity (PWV). Results: 150 patients did have a metabolic syndrome (MetS+) and 198 did not (MetS-). PWV is higher in MetS+ patients, but it does not sustain after adjustment with confounding factors. Within this population, 93 have diabetes mellitus and multiple parameter correlation of PWV with each of MetS components in this population show a significant association with glucose metabolism impairment only. MetS+ no diabetes diabetes p (n=150) (n=57) (n=93) PWV (m/s) 13.74±3.66 12.71±3.49 14.35±3.65 0.0027 PWV (m/s) (*) 12.94±3.06 14.11±2.99 0.0259 PWV (m/s) (*) & MetS_HDL 12.96±3.15 14.15±3.02 0.0261 PWV (m/s) (*) & MetS_WC 13.07±3.50 14.22±3.55 0.0283 PWV (m/s) (*) & MetS_TG 12.96±3.07 14.08±3.11 0.0371 PWV (m/s) (*) & MetS_HTA 13.79±11.34 15.00±15.06 0.0227 PWV (m/s) (*) & MetS_Glyc 12.93±3.07 13.88±4.98 0.1484 Conclusion: MetS+ patients have a higher PWV than MetS- patients but this difference disappears after adjustment to classic factors. Diabetic patients have a significantly higher PWV even after adjustment. When performing multiple parameter relationship with different components of MetS, we find that only glucose metabolism impairment is independently and positively correlated to PWV.