Biased Opioid Ligands: Revolution or Evolution?
Opioid are the most powerful analgesics ever but their use is still limited by deleterious side effects such as tolerance, dependence, and respiratory depression that could eventually lead to a fatal overdose. The opioid crisis, mainly occurring in north America, stimulates research on finding new o...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Pain Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2021.722820/full |
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doaj-2dcf450cc48a48c8a44019a1b10594532021-09-24T06:30:05ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2021-09-01210.3389/fpain.2021.722820722820Biased Opioid Ligands: Revolution or Evolution?Florence NobleNicolas MarieOpioid are the most powerful analgesics ever but their use is still limited by deleterious side effects such as tolerance, dependence, and respiratory depression that could eventually lead to a fatal overdose. The opioid crisis, mainly occurring in north America, stimulates research on finding new opioid ligands with reduced side effects. Among them, biased ligands are likely the most promising compounds. We will review some of the latest discovered biased opioid ligands and see if they were able to fulfill these expectations.https://www.frontiersin.org/articles/10.3389/fpain.2021.722820/fullopioidsbiased ligandsanalgesiaside effectsTRV130PZM21 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Florence Noble Nicolas Marie |
| spellingShingle |
Florence Noble Nicolas Marie Biased Opioid Ligands: Revolution or Evolution? Frontiers in Pain Research opioids biased ligands analgesia side effects TRV130 PZM21 |
| author_facet |
Florence Noble Nicolas Marie |
| author_sort |
Florence Noble |
| title |
Biased Opioid Ligands: Revolution or Evolution? |
| title_short |
Biased Opioid Ligands: Revolution or Evolution? |
| title_full |
Biased Opioid Ligands: Revolution or Evolution? |
| title_fullStr |
Biased Opioid Ligands: Revolution or Evolution? |
| title_full_unstemmed |
Biased Opioid Ligands: Revolution or Evolution? |
| title_sort |
biased opioid ligands: revolution or evolution? |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Pain Research |
| issn |
2673-561X |
| publishDate |
2021-09-01 |
| description |
Opioid are the most powerful analgesics ever but their use is still limited by deleterious side effects such as tolerance, dependence, and respiratory depression that could eventually lead to a fatal overdose. The opioid crisis, mainly occurring in north America, stimulates research on finding new opioid ligands with reduced side effects. Among them, biased ligands are likely the most promising compounds. We will review some of the latest discovered biased opioid ligands and see if they were able to fulfill these expectations. |
| topic |
opioids biased ligands analgesia side effects TRV130 PZM21 |
| url |
https://www.frontiersin.org/articles/10.3389/fpain.2021.722820/full |
| work_keys_str_mv |
AT florencenoble biasedopioidligandsrevolutionorevolution AT nicolasmarie biasedopioidligandsrevolutionorevolution |
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1717370091298881536 |