Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19
Currently, the majority of treatment strategies reported for coronavirus disease (COVID-19) involve the systemic administration of drugs, in addition to other approaches including convalescent plasma.1,2 The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was believed to...
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European Medical Journal
2021-02-01
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doaj-2ddbd9b7a5ab44a6b441201bcc2fd3022021-02-09T16:37:09ZengEuropean Medical JournalEuropean Medical Journal Innovations2513-86342021-02-01514651Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19George Dangas0Christopher J. White1Nodar Kipshidze2Jawed Fareed3Patrick Iversen4Antonio Colombo5Nicholas Kipshidze6Icahn School of Medicine at Mount Sinai, New York City, New York, USAOchsner Clinical School, University of Queensland, Australia and Ochsner Medical Center, New Orleans, Louisiana, USANYU Langone Health, New York, New York, USADepartment of Pathology and Laboratory Medicine and Department of Pharmacology and Neuroscience, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, Illinois, USAUSAMRID, Fort Detrick, Maryland, USAUniversity Vita e Salute in San Raffaele Hospital and Columbus Hospitals, Milan, ItalyNY Cardiovascular Research, New York City, New York, USACurrently, the majority of treatment strategies reported for coronavirus disease (COVID-19) involve the systemic administration of drugs, in addition to other approaches including convalescent plasma.1,2 The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was believed to be largely localised in the lungs. Retrospective observational studies from Wuhan, China have shown subgroups of patients with symptoms affecting the cardiovascular, renal, nervous, and digestive systems.3,4 Yet the most critical cases largely encompass those suffering from acute respiratory distress syndrome (ARDS). Therefore, the authors propose a combination of local delivery of therapeutics directly to the lungs and adjunct systemic administration (i.e., intravenous infusion).https://www.emjreviews.com/innovations/article/catheter-based-local-delivery-of-therapeutics-to-the-lungs-for-severe-or-critically-ill-patients-with-covid-19/acute respiratory distress syndrome (ards)catheter interventionscoronavirus disease (covid-19)local drug deliveryrespiratory infectionssevere acute respiratory syndrome coronavirus 2 (sars-cov-2) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
George Dangas Christopher J. White Nodar Kipshidze Jawed Fareed Patrick Iversen Antonio Colombo Nicholas Kipshidze |
spellingShingle |
George Dangas Christopher J. White Nodar Kipshidze Jawed Fareed Patrick Iversen Antonio Colombo Nicholas Kipshidze Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19 European Medical Journal Innovations acute respiratory distress syndrome (ards) catheter interventions coronavirus disease (covid-19) local drug delivery respiratory infections severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
author_facet |
George Dangas Christopher J. White Nodar Kipshidze Jawed Fareed Patrick Iversen Antonio Colombo Nicholas Kipshidze |
author_sort |
George Dangas |
title |
Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19 |
title_short |
Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19 |
title_full |
Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19 |
title_fullStr |
Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19 |
title_full_unstemmed |
Catheter-Based Local Delivery of Therapeutics to the Lungs for Severe or Critically Ill Patients with COVID-19 |
title_sort |
catheter-based local delivery of therapeutics to the lungs for severe or critically ill patients with covid-19 |
publisher |
European Medical Journal |
series |
European Medical Journal Innovations |
issn |
2513-8634 |
publishDate |
2021-02-01 |
description |
Currently, the majority of treatment strategies reported for coronavirus disease (COVID-19) involve the systemic administration of drugs, in addition to other approaches including convalescent plasma.1,2 The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was believed to be largely localised in the lungs. Retrospective observational studies from Wuhan, China have shown subgroups of patients with symptoms affecting the cardiovascular, renal, nervous, and digestive systems.3,4 Yet the most critical cases largely encompass those suffering from acute respiratory distress syndrome (ARDS). Therefore, the authors propose a combination of local delivery of therapeutics directly to the lungs and adjunct systemic administration (i.e., intravenous infusion). |
topic |
acute respiratory distress syndrome (ards) catheter interventions coronavirus disease (covid-19) local drug delivery respiratory infections severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
url |
https://www.emjreviews.com/innovations/article/catheter-based-local-delivery-of-therapeutics-to-the-lungs-for-severe-or-critically-ill-patients-with-covid-19/ |
work_keys_str_mv |
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