Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade

Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade

Oral cancer—a type of head and neck cancer—is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. &l...

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Main Authors: Xiao-Fan Huang, Kai-Fu Chang, Shan-Chih Lee, Chia-Yu Li, Hung-Hsiu Liao, Ming-Chang Hsieh, Nu-Man Tsai
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
oral cancer
cisplatin
synergism
cell apoptosis
<i>Juniperus indica Bertol</i>
Online Access:https://www.mdpi.com/1420-3049/25/12/2746
id doaj-2e01267b42cd48069db59d531380d03e
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spelling doaj-2e01267b42cd48069db59d531380d03e2020-11-25T03:38:24ZengMDPI AGMolecules1420-30492020-06-01252746274610.3390/molecules25122746Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase CascadeXiao-Fan Huang0Kai-Fu Chang1Shan-Chih Lee2Chia-Yu Li3Hung-Hsiu Liao4Ming-Chang Hsieh5Nu-Man Tsai6Institute of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Life and Death, Nanhua University, Chiayi 62249, Taiwan,Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, TaiwanOral cancer—a type of head and neck cancer—is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. <i>Juniperus indica Bertol</i> is a plant of the <i>Juniperus</i> genus often used as a treatment in traditional medicine due to its anti-inflammatory, antibacterial and diuretic functions. The biofunctions of <i>Juniperus indica Bertol</i> including its anticancer potential, have not been fully explored. As a result, the aim of this research was to investigate the anticancer activity of <i>Juniperus indica Bertol</i> extract (JIB extract) and determine whether JIB extract has synergistic effects with cisplatin in oral cancer. These results are the first to demonstrate that JIB extract exhibits anticancer capacity and synergizes with cisplatin to treat oral cancer. Our findings indicate that JIB extract has a potential to develop anticancer agent and chemo therapeutic adjuvant for oral cancer.https://www.mdpi.com/1420-3049/25/12/2746oral cancercisplatinsynergismcell apoptosis<i>Juniperus indica Bertol</i>
collection DOAJ
language English
format Article
sources DOAJ
author Xiao-Fan Huang
Kai-Fu Chang
Shan-Chih Lee
Chia-Yu Li
Hung-Hsiu Liao
Ming-Chang Hsieh
Nu-Man Tsai
spellingShingle Xiao-Fan Huang
Kai-Fu Chang
Shan-Chih Lee
Chia-Yu Li
Hung-Hsiu Liao
Ming-Chang Hsieh
Nu-Man Tsai
Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
Molecules
oral cancer
cisplatin
synergism
cell apoptosis
<i>Juniperus indica Bertol</i>
author_facet Xiao-Fan Huang
Kai-Fu Chang
Shan-Chih Lee
Chia-Yu Li
Hung-Hsiu Liao
Ming-Chang Hsieh
Nu-Man Tsai
author_sort Xiao-Fan Huang
title Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_short Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_full Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_fullStr Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_full_unstemmed Extract of <i>Juniperus indica Bertol</i> Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth via Repression of Cell Cycle Progression and Activation of the Caspase Cascade
title_sort extract of <i>juniperus indica bertol</i> synergizes with cisplatin to inhibit oral cancer cell growth via repression of cell cycle progression and activation of the caspase cascade
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-06-01
description Oral cancer—a type of head and neck cancer—is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. <i>Juniperus indica Bertol</i> is a plant of the <i>Juniperus</i> genus often used as a treatment in traditional medicine due to its anti-inflammatory, antibacterial and diuretic functions. The biofunctions of <i>Juniperus indica Bertol</i> including its anticancer potential, have not been fully explored. As a result, the aim of this research was to investigate the anticancer activity of <i>Juniperus indica Bertol</i> extract (JIB extract) and determine whether JIB extract has synergistic effects with cisplatin in oral cancer. These results are the first to demonstrate that JIB extract exhibits anticancer capacity and synergizes with cisplatin to treat oral cancer. Our findings indicate that JIB extract has a potential to develop anticancer agent and chemo therapeutic adjuvant for oral cancer.
topic oral cancer
cisplatin
synergism
cell apoptosis
<i>Juniperus indica Bertol</i>
url https://www.mdpi.com/1420-3049/25/12/2746
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