A rare urinary JC virus reactivation after long-term therapy with rituximab

The possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a lymphoproliferative disorder is reported herein. The pa...

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Main Authors:	Fabrizio Di Maida, Lorenzo Viola, Luca Lambertini, Andrea Mari, Jessica Mencarini, Beatrice Borchi, Marco Carini, Lorenzo Zammarchi, Andrea Minervini
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	International Journal of Infectious Diseases
Subjects:	Infection JC virus Polyomavirus Rituximab Reactivation Urinary
Online Access:	http://www.sciencedirect.com/science/article/pii/S1201971220325091

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spelling	doaj-2e03fa9c679c480aa7f1679cb07ad39e2021-02-07T04:21:54ZengElsevierInternational Journal of Infectious Diseases1201-97122021-02-01103447449A rare urinary JC virus reactivation after long-term therapy with rituximabFabrizio Di Maida0Lorenzo Viola1Luca Lambertini2Andrea Mari3Jessica Mencarini4Beatrice Borchi5Marco Carini6Lorenzo Zammarchi7Andrea Minervini8Department of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Corresponding author at: Department of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, San Luca Nuovo, Firenze, Italy.Department of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Infectious and Tropical Diseases Unit, AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Infectious and Tropical Diseases Unit, AOU Careggi, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Infectious and Tropical Diseases Unit, AOU Careggi, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyThe possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a lymphoproliferative disorder is reported herein. The patient developed severe renal and urinary tract impairment, characterized by the onset of nephropathy, bilateral ureteral strictures, and a serious reduction in vesical compliance, ultimately requiring an ileal neobladder configuration. The renal and urinary tract involvement was finally attributed to JC virus reactivation. This observation suggests that renal and urinary tract diseases related to JC virus might be associated with long-term rituximab treatment.http://www.sciencedirect.com/science/article/pii/S1201971220325091InfectionJC virusPolyomavirusRituximabReactivationUrinary
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fabrizio Di Maida Lorenzo Viola Luca Lambertini Andrea Mari Jessica Mencarini Beatrice Borchi Marco Carini Lorenzo Zammarchi Andrea Minervini
spellingShingle	Fabrizio Di Maida Lorenzo Viola Luca Lambertini Andrea Mari Jessica Mencarini Beatrice Borchi Marco Carini Lorenzo Zammarchi Andrea Minervini A rare urinary JC virus reactivation after long-term therapy with rituximab International Journal of Infectious Diseases Infection JC virus Polyomavirus Rituximab Reactivation Urinary
author_facet	Fabrizio Di Maida Lorenzo Viola Luca Lambertini Andrea Mari Jessica Mencarini Beatrice Borchi Marco Carini Lorenzo Zammarchi Andrea Minervini
author_sort	Fabrizio Di Maida
title	A rare urinary JC virus reactivation after long-term therapy with rituximab
title_short	A rare urinary JC virus reactivation after long-term therapy with rituximab
title_full	A rare urinary JC virus reactivation after long-term therapy with rituximab
title_fullStr	A rare urinary JC virus reactivation after long-term therapy with rituximab
title_full_unstemmed	A rare urinary JC virus reactivation after long-term therapy with rituximab
title_sort	rare urinary jc virus reactivation after long-term therapy with rituximab
publisher	Elsevier
series	International Journal of Infectious Diseases
issn	1201-9712
publishDate	2021-02-01
description	The possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a lymphoproliferative disorder is reported herein. The patient developed severe renal and urinary tract impairment, characterized by the onset of nephropathy, bilateral ureteral strictures, and a serious reduction in vesical compliance, ultimately requiring an ileal neobladder configuration. The renal and urinary tract involvement was finally attributed to JC virus reactivation. This observation suggests that renal and urinary tract diseases related to JC virus might be associated with long-term rituximab treatment.
topic	Infection JC virus Polyomavirus Rituximab Reactivation Urinary
url	http://www.sciencedirect.com/science/article/pii/S1201971220325091
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A rare urinary JC virus reactivation after long-term therapy with rituximab

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