A rare urinary JC virus reactivation after long-term therapy with rituximab
The possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a lymphoproliferative disorder is reported herein. The pa...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-02-01
|
Series: | International Journal of Infectious Diseases |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220325091 |
id |
doaj-2e03fa9c679c480aa7f1679cb07ad39e |
---|---|
record_format |
Article |
spelling |
doaj-2e03fa9c679c480aa7f1679cb07ad39e2021-02-07T04:21:54ZengElsevierInternational Journal of Infectious Diseases1201-97122021-02-01103447449A rare urinary JC virus reactivation after long-term therapy with rituximabFabrizio Di Maida0Lorenzo Viola1Luca Lambertini2Andrea Mari3Jessica Mencarini4Beatrice Borchi5Marco Carini6Lorenzo Zammarchi7Andrea Minervini8Department of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Corresponding author at: Department of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, San Luca Nuovo, Firenze, Italy.Department of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Infectious and Tropical Diseases Unit, AOU Careggi, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Infectious and Tropical Diseases Unit, AOU Careggi, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Infectious and Tropical Diseases Unit, AOU Careggi, Florence, ItalyDepartment of Urology, University of Florence, Unit of Oncologic Minimally Invasive Urology and Andrology, Careggi Hospital, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyThe possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a lymphoproliferative disorder is reported herein. The patient developed severe renal and urinary tract impairment, characterized by the onset of nephropathy, bilateral ureteral strictures, and a serious reduction in vesical compliance, ultimately requiring an ileal neobladder configuration. The renal and urinary tract involvement was finally attributed to JC virus reactivation. This observation suggests that renal and urinary tract diseases related to JC virus might be associated with long-term rituximab treatment.http://www.sciencedirect.com/science/article/pii/S1201971220325091InfectionJC virusPolyomavirusRituximabReactivationUrinary |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabrizio Di Maida Lorenzo Viola Luca Lambertini Andrea Mari Jessica Mencarini Beatrice Borchi Marco Carini Lorenzo Zammarchi Andrea Minervini |
spellingShingle |
Fabrizio Di Maida Lorenzo Viola Luca Lambertini Andrea Mari Jessica Mencarini Beatrice Borchi Marco Carini Lorenzo Zammarchi Andrea Minervini A rare urinary JC virus reactivation after long-term therapy with rituximab International Journal of Infectious Diseases Infection JC virus Polyomavirus Rituximab Reactivation Urinary |
author_facet |
Fabrizio Di Maida Lorenzo Viola Luca Lambertini Andrea Mari Jessica Mencarini Beatrice Borchi Marco Carini Lorenzo Zammarchi Andrea Minervini |
author_sort |
Fabrizio Di Maida |
title |
A rare urinary JC virus reactivation after long-term therapy with rituximab |
title_short |
A rare urinary JC virus reactivation after long-term therapy with rituximab |
title_full |
A rare urinary JC virus reactivation after long-term therapy with rituximab |
title_fullStr |
A rare urinary JC virus reactivation after long-term therapy with rituximab |
title_full_unstemmed |
A rare urinary JC virus reactivation after long-term therapy with rituximab |
title_sort |
rare urinary jc virus reactivation after long-term therapy with rituximab |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-02-01 |
description |
The possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a lymphoproliferative disorder is reported herein. The patient developed severe renal and urinary tract impairment, characterized by the onset of nephropathy, bilateral ureteral strictures, and a serious reduction in vesical compliance, ultimately requiring an ileal neobladder configuration. The renal and urinary tract involvement was finally attributed to JC virus reactivation. This observation suggests that renal and urinary tract diseases related to JC virus might be associated with long-term rituximab treatment. |
topic |
Infection JC virus Polyomavirus Rituximab Reactivation Urinary |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220325091 |
work_keys_str_mv |
AT fabriziodimaida arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT lorenzoviola arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT lucalambertini arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT andreamari arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT jessicamencarini arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT beatriceborchi arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT marcocarini arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT lorenzozammarchi arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT andreaminervini arareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT fabriziodimaida rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT lorenzoviola rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT lucalambertini rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT andreamari rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT jessicamencarini rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT beatriceborchi rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT marcocarini rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT lorenzozammarchi rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab AT andreaminervini rareurinaryjcvirusreactivationafterlongtermtherapywithrituximab |
_version_ |
1724281885520035840 |