Eco-Friendly UPLC–MS/MS Method for Determination of a Fostamatinib Metabolite, Tamatinib, in Plasma: Pharmacokinetic Application in Rats

Eco-Friendly UPLC–MS/MS Method for Determination of a Fostamatinib Metabolite, Tamatinib, in Plasma: Pharmacokinetic Application in Rats

Fostamatinib is a prodrug of the active metabolite tamatinib, which is a spleen tyrosine kinase (Syk) inhibitor used in the treatment of primary chronic adult immune thrombocytopenia and rheumatoid arthritis. A highly sensitive, rapid, reliable, and green method was developed and validated using ult...

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Bibliographic Details
Main Authors: Essam Ezzeldin, Muzaffar Iqbal, Yousif A. Asiri, Ahmed Y. A. Sayed, Rashad Alsalahi
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
fostamatinib
tamatinib
UPLC–MS/MS
pharmacokinetics
rat
Online Access:https://www.mdpi.com/1420-3049/26/15/4663

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