Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and is characterized by inflammation, demyelination, and axonal loss. Fingolimod is the first oral drug for the treatment of MS approved by the United States Food and Drug Administration, European Union countries,...
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Galenos Yayinevi
2017-12-01
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doaj-2e0e55ded7ff4ac69f63f666b54929ce2021-09-02T21:52:21ZengGalenos YayineviTürk Nöroloji Dergisi1301-062X1309-25452017-12-0123417618510.4274/tnd.62144Fingolimod for the Treatment of Relapsing-Remitting Multiple SclerosisBurcu Altunrende0Erkingül Birday1Mithat Kasap2Gülşen Akman Demir3Istanbul Bilim University Faculty of Medicine, Department of Neurology, Istanbul, TurkeyMedipol Mega University Hospital, Department of Neurology, Istanbul, TurkeyNovartis Pharmaceuticals Turkey, Istanbul, TurkeyIstanbul Bilim University Faculty of Medicine, Department of Neurology, Istanbul, TurkeyMultiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and is characterized by inflammation, demyelination, and axonal loss. Fingolimod is the first oral drug for the treatment of MS approved by the United States Food and Drug Administration, European Union countries, and various other countries. The compound exerts its effect via interaction with lysophospholipid receptors known as sphingosine-1 phosphate receptors. Although fingolimod has a very convenient daily oral dosing, it may cause development of bradycardia at the first dose, macular edema, infection, all of which require attention. Randomized double-blind clinical trials have shown that fingolimod significantly reduces relapse rates and is beneficial in brain magnetic resonance imaging measures when compared with both placebo and intramuscular interferon β-1a. This review describes the characteristics of fingolimod concerning its efficacy, safety, and tolerability in the clinical context of the management of MShttp://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-62144Multiple sclerosisfingolimodsphingosine-1 phosphateefficacysafety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Burcu Altunrende Erkingül Birday Mithat Kasap Gülşen Akman Demir |
spellingShingle |
Burcu Altunrende Erkingül Birday Mithat Kasap Gülşen Akman Demir Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis Türk Nöroloji Dergisi Multiple sclerosis fingolimod sphingosine-1 phosphate efficacy safety |
author_facet |
Burcu Altunrende Erkingül Birday Mithat Kasap Gülşen Akman Demir |
author_sort |
Burcu Altunrende |
title |
Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis |
title_short |
Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis |
title_full |
Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis |
title_fullStr |
Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis |
title_full_unstemmed |
Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis |
title_sort |
fingolimod for the treatment of relapsing-remitting multiple sclerosis |
publisher |
Galenos Yayinevi |
series |
Türk Nöroloji Dergisi |
issn |
1301-062X 1309-2545 |
publishDate |
2017-12-01 |
description |
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and is characterized by inflammation, demyelination, and axonal loss. Fingolimod is the first oral drug for the treatment of MS approved by the United States Food and Drug Administration, European Union countries, and various other countries. The compound exerts its effect via interaction with lysophospholipid receptors known as sphingosine-1 phosphate receptors. Although fingolimod has a very convenient daily oral dosing, it may cause development of bradycardia at the first dose, macular edema, infection, all of which require attention. Randomized double-blind clinical trials have shown that fingolimod significantly reduces relapse rates and is beneficial in brain magnetic resonance imaging measures when compared with both placebo and intramuscular interferon β-1a. This review describes the characteristics of fingolimod concerning its efficacy, safety, and tolerability in the clinical context of the management of MS |
topic |
Multiple sclerosis fingolimod sphingosine-1 phosphate efficacy safety |
url |
http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-62144 |
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