Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease
Objective: To investigate the changes and significance of serum inflammatory factors, uric acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels in patients with coronary heart disease (CHD). Methods: A total of 152 patients with CHD were selected as the CHD group...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-10-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201719/02.pdf |
Summary: | Objective: To investigate the changes and significance of serum inflammatory factors, uric
acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels
in patients with coronary heart disease (CHD). Methods: A total of 152 patients with CHD
were selected as the CHD group, including stable angina pectoris (SAP group, n=48), unstable
angina pectoris (UAP group, n=55), and acute myocardial infarction (AMI group, n=49),
according to the Gensinis score, it can be divided into mild group (n=88), moderate group
(n=43) and severe group (n=21), at the same time 55 healthy people were selected as control
group. The serum inflammatory factors [hypersensitivity C reactive protein (hs-CRP), tumor
necrosis factor -α (TNF-α)], UA, Hcy and sdLDL-C levels were compared between patients
with different CHD and different degree of coronary artery lesions. Results: The levels of hs-
CRP, TNF-α, UA, Hcy and sdLDL-C in the CHD group were significantly higher than those in
the control group; In the CHD group, the levels of hs-CRP, TNF-α, UA, Hcy and sdLDL-C
in the UAP group and AMI group were significantly higher than those off the SAP group,
and the level of AMI group [(7.96±1.49) mg/L, (92.87±14.50) ng/L, (417.75±43.88) mol/
L, (23.25±7.33) and mol/L (1.31±0.53) mmol/L] was significantly higher than that of UAP
group [(6.15±0.97) mg/L, (73.88±9.27) ng/L, (393.63±68.29) mol/L, (19.67±7.26) mol/L and
(1.08±0.44) mmol/L]; Compared with mild group hs-CRP, TNF-α, UA, Hcy and sdLDL-C
levels, the levels of the moderate group and severe group were significantly increased, and the
level of severe group was significantly higher than that of moderate group. Conclusion: The
levels of serum inflammatory factors, UA, Hcy and sdLDL-C in patients with coronary heart
disease are significantly increased, and the detection of the levels has a great significance for
the diagnosis of coronary heart disease and the assessment of the severity of coronary heart
disease. |
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ISSN: | 1007-1237 1007-1237 |