Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease
Objective: To investigate the changes and significance of serum inflammatory factors, uric acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels in patients with coronary heart disease (CHD). Methods: A total of 152 patients with CHD were selected as the CHD group...
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doaj-2e155488e4104541abb93566f00b73762020-11-25T02:51:43ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-10-012319710Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart diseaseZhi-Qiong Li0Chuan-Ying Xie1Yan Wang2Department of Clinical Laboratory, Yiling Hospital, Hubei, Yichang 443100, ChinaDepartment of Clinical Laboratory, Yichang Third People ' s Hospital, Hubei, Yichang 443000, ChinaDepartment of Clinical Laboratory, Dangyang maternal and Child Health Hospital, Hubei, Dangyang 444100, ChinaObjective: To investigate the changes and significance of serum inflammatory factors, uric acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels in patients with coronary heart disease (CHD). Methods: A total of 152 patients with CHD were selected as the CHD group, including stable angina pectoris (SAP group, n=48), unstable angina pectoris (UAP group, n=55), and acute myocardial infarction (AMI group, n=49), according to the Gensinis score, it can be divided into mild group (n=88), moderate group (n=43) and severe group (n=21), at the same time 55 healthy people were selected as control group. The serum inflammatory factors [hypersensitivity C reactive protein (hs-CRP), tumor necrosis factor -α (TNF-α)], UA, Hcy and sdLDL-C levels were compared between patients with different CHD and different degree of coronary artery lesions. Results: The levels of hs- CRP, TNF-α, UA, Hcy and sdLDL-C in the CHD group were significantly higher than those in the control group; In the CHD group, the levels of hs-CRP, TNF-α, UA, Hcy and sdLDL-C in the UAP group and AMI group were significantly higher than those off the SAP group, and the level of AMI group [(7.96±1.49) mg/L, (92.87±14.50) ng/L, (417.75±43.88) mol/ L, (23.25±7.33) and mol/L (1.31±0.53) mmol/L] was significantly higher than that of UAP group [(6.15±0.97) mg/L, (73.88±9.27) ng/L, (393.63±68.29) mol/L, (19.67±7.26) mol/L and (1.08±0.44) mmol/L]; Compared with mild group hs-CRP, TNF-α, UA, Hcy and sdLDL-C levels, the levels of the moderate group and severe group were significantly increased, and the level of severe group was significantly higher than that of moderate group. Conclusion: The levels of serum inflammatory factors, UA, Hcy and sdLDL-C in patients with coronary heart disease are significantly increased, and the detection of the levels has a great significance for the diagnosis of coronary heart disease and the assessment of the severity of coronary heart disease.http://www.hnykdxxb.com/PDF/201719/02.pdfCoronary heart diseaseSerum inflammatory factorsUAHcysdLDL-C |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhi-Qiong Li Chuan-Ying Xie Yan Wang |
spellingShingle |
Zhi-Qiong Li Chuan-Ying Xie Yan Wang Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease Journal of Hainan Medical University Coronary heart disease Serum inflammatory factors UA Hcy sdLDL-C |
author_facet |
Zhi-Qiong Li Chuan-Ying Xie Yan Wang |
author_sort |
Zhi-Qiong Li |
title |
Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease |
title_short |
Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease |
title_full |
Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease |
title_fullStr |
Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease |
title_full_unstemmed |
Changes and significance of serum inflammatory factors, UA, Hcy and small dense low-density lipoprotein levels in patients with coronary heart disease |
title_sort |
changes and significance of serum inflammatory factors, ua, hcy and small dense low-density lipoprotein levels in patients with coronary heart disease |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-10-01 |
description |
Objective: To investigate the changes and significance of serum inflammatory factors, uric
acid (UA), homocysteine (Hcy) and small dense low-density lipoprotein (sdLDL-C) levels
in patients with coronary heart disease (CHD). Methods: A total of 152 patients with CHD
were selected as the CHD group, including stable angina pectoris (SAP group, n=48), unstable
angina pectoris (UAP group, n=55), and acute myocardial infarction (AMI group, n=49),
according to the Gensinis score, it can be divided into mild group (n=88), moderate group
(n=43) and severe group (n=21), at the same time 55 healthy people were selected as control
group. The serum inflammatory factors [hypersensitivity C reactive protein (hs-CRP), tumor
necrosis factor -α (TNF-α)], UA, Hcy and sdLDL-C levels were compared between patients
with different CHD and different degree of coronary artery lesions. Results: The levels of hs-
CRP, TNF-α, UA, Hcy and sdLDL-C in the CHD group were significantly higher than those in
the control group; In the CHD group, the levels of hs-CRP, TNF-α, UA, Hcy and sdLDL-C
in the UAP group and AMI group were significantly higher than those off the SAP group,
and the level of AMI group [(7.96±1.49) mg/L, (92.87±14.50) ng/L, (417.75±43.88) mol/
L, (23.25±7.33) and mol/L (1.31±0.53) mmol/L] was significantly higher than that of UAP
group [(6.15±0.97) mg/L, (73.88±9.27) ng/L, (393.63±68.29) mol/L, (19.67±7.26) mol/L and
(1.08±0.44) mmol/L]; Compared with mild group hs-CRP, TNF-α, UA, Hcy and sdLDL-C
levels, the levels of the moderate group and severe group were significantly increased, and the
level of severe group was significantly higher than that of moderate group. Conclusion: The
levels of serum inflammatory factors, UA, Hcy and sdLDL-C in patients with coronary heart
disease are significantly increased, and the detection of the levels has a great significance for
the diagnosis of coronary heart disease and the assessment of the severity of coronary heart
disease. |
topic |
Coronary heart disease Serum inflammatory factors UA Hcy sdLDL-C |
url |
http://www.hnykdxxb.com/PDF/201719/02.pdf |
work_keys_str_mv |
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