Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]

Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]

The search for a “pain centre” in the brain has long eluded neuroscientists.  Although many regions of the brain have been shown to respond to painful stimuli, all of these regions also respond to other types of salient stimuli. In a recent paper, Segerdahl et al. (Nature Neuroscience, 2015)  claims...

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Main Authors: Karen D. Davis, M. Catherine Bushnell, Gian Domenico Iannetti, Keith St. Lawrence, Robert Coghill
Format: Article
Language:English
Published: F1000 Research Ltd 2015-07-01
Series:F1000Research
Subjects:
Pain: Basic Science
Online Access:http://f1000research.com/articles/4-362/v1
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spelling doaj-2e1983ec309a48cea21ca0c7f6a855292020-11-25T03:32:09ZengF1000 Research LtdF1000Research2046-14022015-07-01410.12688/f1000research.6833.17347Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]Karen D. Davis0M. Catherine Bushnell1Gian Domenico Iannetti2Keith St. Lawrence3Robert Coghill4Joint Department of Medical Imaging, University Health Network, Toronto, ON, M5T 2S8, CanadaPain and Integrative Neuroscience Branch, Division of Intramural Research, National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, 20892-1302, USADepartment of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UKDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 4V2, CanadaDepartment of Anesthesiology, Cincinnati Children’s Hospital, Cincinnati, OH, 45229-3026, USAThe search for a “pain centre” in the brain has long eluded neuroscientists.  Although many regions of the brain have been shown to respond to painful stimuli, all of these regions also respond to other types of salient stimuli. In a recent paper, Segerdahl et al. (Nature Neuroscience, 2015)  claims that the dorsal posterior insula (dpIns) is a pain-specific region based on the observation that the magnitude of regional cerebral blood flow (rCBF) fluctuations in the dpIns correlated with the magnitude of evoked pain.  However, such a conclusion is, simply, not justified by the experimental evidence provided.  Here we discuss three major factors that seriously question this claim.http://f1000research.com/articles/4-362/v1Pain: Basic Science
collection DOAJ
language English
format Article
sources DOAJ
author Karen D. Davis
M. Catherine Bushnell
Gian Domenico Iannetti
Keith St. Lawrence
Robert Coghill
spellingShingle Karen D. Davis
M. Catherine Bushnell
Gian Domenico Iannetti
Keith St. Lawrence
Robert Coghill
Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]
F1000Research
Pain: Basic Science
author_facet Karen D. Davis
M. Catherine Bushnell
Gian Domenico Iannetti
Keith St. Lawrence
Robert Coghill
author_sort Karen D. Davis
title Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]
title_short Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]
title_full Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]
title_fullStr Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]
title_full_unstemmed Evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]
title_sort evidence against pain specificity in the dorsal posterior insula [version 1; referees: 2 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2015-07-01
description The search for a “pain centre” in the brain has long eluded neuroscientists.  Although many regions of the brain have been shown to respond to painful stimuli, all of these regions also respond to other types of salient stimuli. In a recent paper, Segerdahl et al. (Nature Neuroscience, 2015)  claims that the dorsal posterior insula (dpIns) is a pain-specific region based on the observation that the magnitude of regional cerebral blood flow (rCBF) fluctuations in the dpIns correlated with the magnitude of evoked pain.  However, such a conclusion is, simply, not justified by the experimental evidence provided.  Here we discuss three major factors that seriously question this claim.
topic Pain: Basic Science
url http://f1000research.com/articles/4-362/v1
work_keys_str_mv AT karenddavis evidenceagainstpainspecificityinthedorsalposteriorinsulaversion1referees2approved
AT mcatherinebushnell evidenceagainstpainspecificityinthedorsalposteriorinsulaversion1referees2approved
AT giandomenicoiannetti evidenceagainstpainspecificityinthedorsalposteriorinsulaversion1referees2approved
AT keithstlawrence evidenceagainstpainspecificityinthedorsalposteriorinsulaversion1referees2approved
AT robertcoghill evidenceagainstpainspecificityinthedorsalposteriorinsulaversion1referees2approved
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