CXCL13 as a Biomarker of Immune Activation During Early and Chronic HIV Infection

CXCL13 as a Biomarker of Immune Activation During Early and Chronic HIV Infection

Background: CXCL13 is preferentially secreted by Follicular Helper T cells (TFH) to attract B cells to germinal centers. Plasma levels of CXCL13 have been reported to be elevated during chronic HIV-infection, however there is limited data on such elevation during early phases of infection and on the...

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Main Authors: Vikram Mehraj, Rayoun Ramendra, Stéphane Isnard, Franck P. Dupuy, Bertrand Lebouché, Cecilia Costiniuk, Réjean Thomas, Jason Szabo, Jean-Guy Baril, Benoit Trottier, Pierre Coté, Roger LeBlanc, Madéleine Durand, Carl Chartrand-Lefebvre, Ido Kema, Yonglong Zhang, Malcolm Finkelman, Cécile Tremblay, Jean-Pierre Routy
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
CXCL13
humoral immune response
microbial translocation
inflammation
immune activation
CMV
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00289/full

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