Long Non-Coding RNA and Acute Leukemia

• Main Authors: Gabriela Marisol Cruz-Miranda, Alfredo Hidalgo-Miranda, Diego Alberto Bárcenas-López, Juan Carlos Núñez-Enríquez, Julian Ramírez-Bello, Juan Manuel Mejía-Aranguré, Silvia Jiménez-Morales
• Format: Article
• Language: English
• Published: MDPI AG 2019-02-01
• Series: International Journal of Molecular Sciences
• Subjects: long non-coding RNAs; cancer; acute leukemia; therapeutic targets
• Online Access: https://www.mdpi.com/1422-0067/20/3/735

Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the last decade. In addition to the contribution of these lncRNAs in leukemogenesis, recent studies have suggested that lncRNAs could be used as biomarkers in the diagnosis, prognosis, and therapeutic response in leukemia patients. The focus of this review is to describe the functional classification, biogenesis, and the role of lncRNAs in leukemogenesis, to summarize the evidence about the lncRNAs which are playing a role in AL, and how these genes could be useful as potential therapeutic targets.