Genes expression by using cDNA Microarray in Whallak-tang

• Main Authors: Cheol-kyung Sin, Chae-woo Lee, Sun-ae Yoo, Hyoun-min Youn, Kyung-jeon Jang, Choon-ho Song, Chang-beohm Ahn, Cheol-hong Kim
• Format: Article
• Language: English
• Published: Korean Pharmacopuncture Institute 2008-12-01
• Series: Journal of Pharmacopuncture
• Subjects: Whallak-tang; cDNA microarray; musculoskeletal disease
• Online Access: http://dx.doi.org/10.3831/KPI.2008.11.4.005

Objective : This study was undertaken to determine the effect of Whallak-tang on expression of CD/cytokine Genes. Methods : The expression of CD/Cytokine Genes were examined by cDNA microarray using the human mast cell line(HMC-l). Results : The expression of ATP5F1, FLJ20671, unknown, KIAA0342, OAS2, unknown genes were increased in 200~300% range. The expression of unknown, MDS006, IFITM1, MRPL3, ZNF207, FTH1, FBP1, NRGN, NR1H2, KIAA0747 genes were decreased in 0~33% range. Conclusion : These results would provide important basic data on the possibility of the clinical treatment of Whallaktang in musculoskeletal disease.