Serum Ischaemia-modified Albumin Concentration in Hyperemesis Gravidarum
Introduction:The role of oxidative stress in the pathogenesis of hyperemesis gravidarum (HEG) has been demonstrated in a lot of studies. The present study aimed to compare the ischaemia-modified albumin (IMA) serum levels of patients diagnosed with HEG with healthy pregnant women, and to investigate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2020-07-01
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| Series: | İstanbul Medical Journal |
| Subjects: | |
| Online Access: |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/serum-schaemia-modified-albumin-concentration-in-h/39835
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| Summary: | Introduction:The role of oxidative stress in the pathogenesis of hyperemesis gravidarum (HEG) has been demonstrated in a lot of studies. The present study aimed to compare the ischaemia-modified albumin (IMA) serum levels of patients diagnosed with HEG with healthy pregnant women, and to investigate whether oxidative stress caused increased serum IMA in HEG.Methods:Pregnant women were classified into a group diagnosed with HEG (n=45) and an age- and body mass index-matched control group without HEG (n=45). Serum IMA levels were assessed by the enzyme-linked immunosorbent assay (ELISA) method.Results:Serum IMA levels were higher in the HEG group than the control group (HEG: 8.2±0.2 ng/mL, control: 6.9±0.3 ng/mL, p<0.001).Conclusion:We found that HEG was related to increased maternal serum IMA levels. The high levels of IMA in HEG can be considered as a reflection of increased oxidative stress. |
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| ISSN: | 2619-9793 2148-094X |