Association between oral lichen planus and Epstein–Barr virus in Iranian patients
Background: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate...
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doaj-2e30f59a1ff146f598446abf64480bbb2020-11-24T22:03:55ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362018-01-01231242410.4103/jrms.JRMS_438_17Association between oral lichen planus and Epstein–Barr virus in Iranian patientsMatin ShariatiMojgan MokhtariAria MasoudifarBackground: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate the presence of Epstein–Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. Materials and Methods: The study was carried out on a case group including 38 tissue specimens of patients with histopathological confirmation of OLP and a control group including 38 samples of healthy mucosa. All samples were examined by nested polymerase chain reaction (PCR) method to determine the DNA of EBV. Results: Twenty-two (57.9%) female samples and 16 (42.1%) male samples with OLP were randomly selected as the case group, and 20 (52.6%) female samples and 18 (47.4%) male samples with healthy mucosa as the control group. There was a statistically significant difference in the percentage of EBV positivity between the case (15.8%) and the control groups (P < 0.05); in the case group, three female samples (13.6%) and three male samples (18.8%) were infected with EBV; the difference between the genders was not statistically significant (P = 0.50). Conclusion: Results emphasized that EBV genome was significantly higher among Iranian patients with OLP so antiviral therapy might be helpful.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=24;epage=24;aulast=ShariatiEpstein–Barr virus infectionsoral lichen planuspolymerase chain reaction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matin Shariati Mojgan Mokhtari Aria Masoudifar |
spellingShingle |
Matin Shariati Mojgan Mokhtari Aria Masoudifar Association between oral lichen planus and Epstein–Barr virus in Iranian patients Journal of Research in Medical Sciences Epstein–Barr virus infections oral lichen planus polymerase chain reaction |
author_facet |
Matin Shariati Mojgan Mokhtari Aria Masoudifar |
author_sort |
Matin Shariati |
title |
Association between oral lichen planus and Epstein–Barr virus in Iranian patients |
title_short |
Association between oral lichen planus and Epstein–Barr virus in Iranian patients |
title_full |
Association between oral lichen planus and Epstein–Barr virus in Iranian patients |
title_fullStr |
Association between oral lichen planus and Epstein–Barr virus in Iranian patients |
title_full_unstemmed |
Association between oral lichen planus and Epstein–Barr virus in Iranian patients |
title_sort |
association between oral lichen planus and epstein–barr virus in iranian patients |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2018-01-01 |
description |
Background: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate the presence of Epstein–Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. Materials and Methods: The study was carried out on a case group including 38 tissue specimens of patients with histopathological confirmation of OLP and a control group including 38 samples of healthy mucosa. All samples were examined by nested polymerase chain reaction (PCR) method to determine the DNA of EBV. Results: Twenty-two (57.9%) female samples and 16 (42.1%) male samples with OLP were randomly selected as the case group, and 20 (52.6%) female samples and 18 (47.4%) male samples with healthy mucosa as the control group. There was a statistically significant difference in the percentage of EBV positivity between the case (15.8%) and the control groups (P < 0.05); in the case group, three female samples (13.6%) and three male samples (18.8%) were infected with EBV; the difference between the genders was not statistically significant (P = 0.50). Conclusion: Results emphasized that EBV genome was significantly higher among Iranian patients with OLP so antiviral therapy might be helpful. |
topic |
Epstein–Barr virus infections oral lichen planus polymerase chain reaction |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=24;epage=24;aulast=Shariati |
work_keys_str_mv |
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