Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys
Low pathogenic avian influenza (LPAI) viruses can silently circulate in poultry and wild aquatic birds and potentially mutate into highly pathogenic avian influenza (HPAI) viruses. In the U.S., recent emergence and spread of H7N8 and H7N9 HPAI viruses not only caused devastating losses to domestic p...
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doaj-2e3369d129154a82b02f6f25e62194972020-11-24T21:16:12ZengMDPI AGViruses1999-49152019-02-0111216310.3390/v11020163v11020163Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and TurkeysIshita Roy Chowdhury0Sai Goutham Reddy Yeddula1Shin-Hee Kim2VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USAVA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USAVA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USALow pathogenic avian influenza (LPAI) viruses can silently circulate in poultry and wild aquatic birds and potentially mutate into highly pathogenic avian influenza (HPAI) viruses. In the U.S., recent emergence and spread of H7N8 and H7N9 HPAI viruses not only caused devastating losses to domestic poultry but also underscored the capability of LPAI viruses to mutate into HPAI viruses. Therefore, in this study, we evaluated pathogenicity and transmissibility of H7N8 and H7N9 LPAI viruses (the progenitors of HPAI viruses) in chickens and turkeys. We also included H7N2 isolated from an outbreak of LPAI in commercial chickens. H7 viruses replicated more efficiently in the respiratory tract than in the gastrointestinal tract, suggesting that their replication is restricted to the upper respiratory tract. Specifically, H7N2 replicated most efficiently in two-week-old chickens and turkeys. In contrast, H7N8 replicated least efficiently in those birds. Further, replication of H7N2 and H7N9 was restricted in the upper respiratory tract of four-week-old specific-pathogen-free (SPF) and broiler chickens. Despite their restricted replication, the two viruses efficiently transmitted from infected to naïve birds by direct contact, leading to seroconversion of contacted chickens. Our findings suggest the importance of continuous monitoring and surveillance of LPAI viruses in the fields.https://www.mdpi.com/1999-4915/11/2/163low pathogenic avian influenza virusH7replicationtransmissibilitychickens |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ishita Roy Chowdhury Sai Goutham Reddy Yeddula Shin-Hee Kim |
spellingShingle |
Ishita Roy Chowdhury Sai Goutham Reddy Yeddula Shin-Hee Kim Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys Viruses low pathogenic avian influenza virus H7 replication transmissibility chickens |
author_facet |
Ishita Roy Chowdhury Sai Goutham Reddy Yeddula Shin-Hee Kim |
author_sort |
Ishita Roy Chowdhury |
title |
Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys |
title_short |
Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys |
title_full |
Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys |
title_fullStr |
Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys |
title_full_unstemmed |
Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys |
title_sort |
pathogenicity and transmissibility of north american h7 low pathogenic avian influenza viruses in chickens and turkeys |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2019-02-01 |
description |
Low pathogenic avian influenza (LPAI) viruses can silently circulate in poultry and wild aquatic birds and potentially mutate into highly pathogenic avian influenza (HPAI) viruses. In the U.S., recent emergence and spread of H7N8 and H7N9 HPAI viruses not only caused devastating losses to domestic poultry but also underscored the capability of LPAI viruses to mutate into HPAI viruses. Therefore, in this study, we evaluated pathogenicity and transmissibility of H7N8 and H7N9 LPAI viruses (the progenitors of HPAI viruses) in chickens and turkeys. We also included H7N2 isolated from an outbreak of LPAI in commercial chickens. H7 viruses replicated more efficiently in the respiratory tract than in the gastrointestinal tract, suggesting that their replication is restricted to the upper respiratory tract. Specifically, H7N2 replicated most efficiently in two-week-old chickens and turkeys. In contrast, H7N8 replicated least efficiently in those birds. Further, replication of H7N2 and H7N9 was restricted in the upper respiratory tract of four-week-old specific-pathogen-free (SPF) and broiler chickens. Despite their restricted replication, the two viruses efficiently transmitted from infected to naïve birds by direct contact, leading to seroconversion of contacted chickens. Our findings suggest the importance of continuous monitoring and surveillance of LPAI viruses in the fields. |
topic |
low pathogenic avian influenza virus H7 replication transmissibility chickens |
url |
https://www.mdpi.com/1999-4915/11/2/163 |
work_keys_str_mv |
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