The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i>
Neutrophils are key to host defence, and impaired neutrophil function predisposes to infection with an array of pathogens, with <i>Staphylococcus aureus</i> a common and sometimes life-threatening problem in this setting. Both infiltrating immune cells and replicating bacteria consume ox...
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doaj-2e360f113af543b1ac2ff8add075fd142020-11-24T22:09:34ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-11-012022556110.3390/ijms20225561ijms20225561The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i>Natalia H Hajdamowicz0Rebecca C Hull1Simon J Foster2Alison M Condliffe3Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Beech Hill Road, Sheffield S10 2TN, UKDepartment of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Beech Hill Road, Sheffield S10 2TN, UKFlorey Institute, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UKDepartment of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Beech Hill Road, Sheffield S10 2TN, UKNeutrophils are key to host defence, and impaired neutrophil function predisposes to infection with an array of pathogens, with <i>Staphylococcus aureus</i> a common and sometimes life-threatening problem in this setting. Both infiltrating immune cells and replicating bacteria consume oxygen, contributing to the profound tissue hypoxia that characterises sites of infection. Hypoxia in turn has a dramatic effect on both neutrophil bactericidal function and the properties of <i>S. aureus</i>, including the production of virulence factors. Hypoxia thereby shapes the host−pathogen interaction and the progression of infection, for example promoting intracellular bacterial persistence, enabling local tissue destruction with the formation of an encaging abscess capsule, and facilitating the establishment and propagation of bacterial biofilms which block the access of host immune cells. Elucidating the molecular mechanisms underlying host−pathogen interactions in the setting of hypoxia will enable better understanding of persistent and recalcitrant infections due to <i>S. aureus</i> and may uncover novel therapeutic targets and strategies.https://www.mdpi.com/1422-0067/20/22/5561neutrophilshost-pathogen interactionhypoxia<i>staphylococcus aureus</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Natalia H Hajdamowicz Rebecca C Hull Simon J Foster Alison M Condliffe |
spellingShingle |
Natalia H Hajdamowicz Rebecca C Hull Simon J Foster Alison M Condliffe The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i> International Journal of Molecular Sciences neutrophils host-pathogen interaction hypoxia <i>staphylococcus aureus</i> |
author_facet |
Natalia H Hajdamowicz Rebecca C Hull Simon J Foster Alison M Condliffe |
author_sort |
Natalia H Hajdamowicz |
title |
The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i> |
title_short |
The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i> |
title_full |
The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i> |
title_fullStr |
The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i> |
title_full_unstemmed |
The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and <i>Staphylococcus aureus</i> |
title_sort |
impact of hypoxia on the host-pathogen interaction between neutrophils and <i>staphylococcus aureus</i> |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-11-01 |
description |
Neutrophils are key to host defence, and impaired neutrophil function predisposes to infection with an array of pathogens, with <i>Staphylococcus aureus</i> a common and sometimes life-threatening problem in this setting. Both infiltrating immune cells and replicating bacteria consume oxygen, contributing to the profound tissue hypoxia that characterises sites of infection. Hypoxia in turn has a dramatic effect on both neutrophil bactericidal function and the properties of <i>S. aureus</i>, including the production of virulence factors. Hypoxia thereby shapes the host−pathogen interaction and the progression of infection, for example promoting intracellular bacterial persistence, enabling local tissue destruction with the formation of an encaging abscess capsule, and facilitating the establishment and propagation of bacterial biofilms which block the access of host immune cells. Elucidating the molecular mechanisms underlying host−pathogen interactions in the setting of hypoxia will enable better understanding of persistent and recalcitrant infections due to <i>S. aureus</i> and may uncover novel therapeutic targets and strategies. |
topic |
neutrophils host-pathogen interaction hypoxia <i>staphylococcus aureus</i> |
url |
https://www.mdpi.com/1422-0067/20/22/5561 |
work_keys_str_mv |
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