Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia

Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia

Molecular epidemiological data on Group A <i>Streptococcus</i> (GAS) infection in Africa is scarce. We characterized the <i>emm-</i>types and <i>emm</i>-clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the pot...

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Main Authors: Sona Jabang, Annette Erhart, Saffiatou Darboe, Aru-Kumba Baldeh, Valerie Delforge, Gabriella Watson, Ebenezer Foster-Nyarko, Rasheed Salaudeen, Bolarinde Lawal, Grant Mackenzie, Anne Botteaux, Martin Antonio, Pierre R. Smeesters, on behalf of The MRCG StrepA Study Group
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Vaccines
Subjects:
group A <i>streptococcus</i>
<i>emm</i>-type
<i>emm</i>-cluster
vaccine
The Gambia
Online Access:https://www.mdpi.com/2076-393X/9/2/124
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spelling doaj-2e3945de3d7840a09be7d6f7f1a88b5e2021-02-05T00:03:45ZengMDPI AGVaccines2076-393X2021-02-01912412410.3390/vaccines9020124Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The GambiaSona Jabang0Annette Erhart1Saffiatou Darboe2Aru-Kumba Baldeh3Valerie Delforge4Gabriella Watson5Ebenezer Foster-Nyarko6Rasheed Salaudeen7Bolarinde Lawal8Grant Mackenzie9Anne Botteaux10Martin Antonio11Pierre R. Smeesters12on behalf of The MRCG StrepA Study GroupMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaLaboratoire de Génétique et Physiologie Bactérienne, IBMM, Université Libre de Bruxelles, 12 Rue des Professeurs Jenner et Brachet, 6041 Gosselies, BelgiumMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaLaboratoire de Génétique et Physiologie Bactérienne, IBMM, Université Libre de Bruxelles, 12 Rue des Professeurs Jenner et Brachet, 6041 Gosselies, BelgiumMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul 273, The GambiaLaboratoire de Génétique et Physiologie Bactérienne, IBMM, Université Libre de Bruxelles, 12 Rue des Professeurs Jenner et Brachet, 6041 Gosselies, BelgiumMolecular epidemiological data on Group A <i>Streptococcus</i> (GAS) infection in Africa is scarce. We characterized the <i>emm-</i>types and <i>emm</i>-clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the potential for strain mistyping, we used a newly published primer for <i>emm</i>-typing. There was considerable strain diversity, highlighting the need for vaccine development offering broad strain protection.https://www.mdpi.com/2076-393X/9/2/124group A <i>streptococcus</i><i>emm</i>-type<i>emm</i>-clustervaccineThe Gambia
collection DOAJ
language English
format Article
sources DOAJ
author Sona Jabang
Annette Erhart
Saffiatou Darboe
Aru-Kumba Baldeh
Valerie Delforge
Gabriella Watson
Ebenezer Foster-Nyarko
Rasheed Salaudeen
Bolarinde Lawal
Grant Mackenzie
Anne Botteaux
Martin Antonio
Pierre R. Smeesters
on behalf of The MRCG StrepA Study Group
spellingShingle Sona Jabang
Annette Erhart
Saffiatou Darboe
Aru-Kumba Baldeh
Valerie Delforge
Gabriella Watson
Ebenezer Foster-Nyarko
Rasheed Salaudeen
Bolarinde Lawal
Grant Mackenzie
Anne Botteaux
Martin Antonio
Pierre R. Smeesters
on behalf of The MRCG StrepA Study Group
Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia
Vaccines
group A <i>streptococcus</i>
<i>emm</i>-type
<i>emm</i>-cluster
vaccine
The Gambia
author_facet Sona Jabang
Annette Erhart
Saffiatou Darboe
Aru-Kumba Baldeh
Valerie Delforge
Gabriella Watson
Ebenezer Foster-Nyarko
Rasheed Salaudeen
Bolarinde Lawal
Grant Mackenzie
Anne Botteaux
Martin Antonio
Pierre R. Smeesters
on behalf of The MRCG StrepA Study Group
author_sort Sona Jabang
title Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia
title_short Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia
title_full Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia
title_fullStr Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia
title_full_unstemmed Molecular Epidemiology of Group A <em>Streptococcus</em> Infections in The Gambia
title_sort molecular epidemiology of group a <em>streptococcus</em> infections in the gambia
publisher MDPI AG
series Vaccines
issn 2076-393X
publishDate 2021-02-01
description Molecular epidemiological data on Group A <i>Streptococcus</i> (GAS) infection in Africa is scarce. We characterized the <i>emm-</i>types and <i>emm</i>-clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the potential for strain mistyping, we used a newly published primer for <i>emm</i>-typing. There was considerable strain diversity, highlighting the need for vaccine development offering broad strain protection.
topic group A <i>streptococcus</i>
<i>emm</i>-type
<i>emm</i>-cluster
vaccine
The Gambia
url https://www.mdpi.com/2076-393X/9/2/124
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