Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model.
Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of these compounds were additionally carried out. Goats demonstrated no signs of acute toxicity, when trea...
Main Authors: | Kirsten Gillingwater, Carlos Gutierrez, Arlene Bridges, Huali Wu, Stijn Deborggraeve, Rosine Ali Ekangu, Arvind Kumar, Mohamed Ismail, David Boykin, Reto Brun |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3117839?pdf=render |
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