Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone
Abstract Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude co...
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doaj-2e76d91027bd424d8f60f7ee709d84d42020-11-24T22:19:42ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-05-013331434143910.1111/jvim.15506Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisoneKrystle L. Reagan0Stanley L. Marks1Patricia A. Pesavento2Ann Della Maggiore3Bing Y. Zhu4Amy M. Grooters5Veterinary Medical Teaching Hospital University of California Davis Davis CaliforniaDepartment of Medicine and Epidemiology, School of Veterinary Medicine University of California Davis CaliforniaDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine University of California Davis CaliforniaVeterinary Medical Teaching Hospital University of California Davis Davis CaliforniaVeterinary Medical Teaching Hospital University of California Davis Davis CaliforniaDepartment of Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University Baton Rouge LouisianaAbstract Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti‐inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible.https://doi.org/10.1111/jvim.15506antifungalcolitisoomycetePythium insidiosum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Krystle L. Reagan Stanley L. Marks Patricia A. Pesavento Ann Della Maggiore Bing Y. Zhu Amy M. Grooters |
spellingShingle |
Krystle L. Reagan Stanley L. Marks Patricia A. Pesavento Ann Della Maggiore Bing Y. Zhu Amy M. Grooters Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone Journal of Veterinary Internal Medicine antifungal colitis oomycete Pythium insidiosum |
author_facet |
Krystle L. Reagan Stanley L. Marks Patricia A. Pesavento Ann Della Maggiore Bing Y. Zhu Amy M. Grooters |
author_sort |
Krystle L. Reagan |
title |
Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone |
title_short |
Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone |
title_full |
Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone |
title_fullStr |
Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone |
title_full_unstemmed |
Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone |
title_sort |
successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone |
publisher |
Wiley |
series |
Journal of Veterinary Internal Medicine |
issn |
0891-6640 1939-1676 |
publishDate |
2019-05-01 |
description |
Abstract Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti‐inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible. |
topic |
antifungal colitis oomycete Pythium insidiosum |
url |
https://doi.org/10.1111/jvim.15506 |
work_keys_str_mv |
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