Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress

Chronic exposure of β-cells to nutrient-rich metabolic stress impairs mitochondrial metabolism and its coupling to insulin secretion. We exposed isolated human islets to different metabolic stresses for 3 days: 0.4 mM oleate or 0.4 mM palmitate at physiological 5.5 mM glucose (lipotoxicity), high 25...

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Bibliographic Details
Main Authors:	Cecilia Jimenez-Sánchez, Thierry Brun, Pierre Maechler
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Biomolecules
Subjects:	pancreatic islets β-cell mitochondria diabetes glucotoxicity glucolipotoxicity
Online Access:	https://www.mdpi.com/2218-273X/10/11/1543

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