Methotrexate induced leucoencephalopathy: A stroke mimic
With increasing usage of thrombolysis in the treatment of acute ischemic strokes within 4.5- hour window, it is becoming more important to recognize stroke mimics. Though the incidence of stroke mimics being thrombolysed is less than 3%, it is essential to diagnose them so as to avoid wrong thrombol...
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doaj-2e9461aac03c476bbf57c84a8e2516282020-11-24T23:15:04ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492013-01-0116341842110.4103/0972-2327.116922Methotrexate induced leucoencephalopathy: A stroke mimicTushar D GosaviMohammed Tauqeer AhmadLai-Heng LeeShih-Hui LimWith increasing usage of thrombolysis in the treatment of acute ischemic strokes within 4.5- hour window, it is becoming more important to recognize stroke mimics. Though the incidence of stroke mimics being thrombolysed is less than 3%, it is essential to diagnose them so as to avoid wrong thrombolytic treatment which carries potential complications of bleeding. We describe the case of a 17 year old girl with acute lymphoblastic leukemia, who developed stroke like episodes on two consecutive challenges with a chemotherapeutic regime which included intravenous and intrathecal methotrexate. She had MRI changes consistent with acute ischemic stroke on both occasions. Her deficits recovered completely and spontaneously, as did the MRI changes. She did not have any further episodes when methotrexate was excluded from the chemotherapeutic regime.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=3;spage=418;epage=421;aulast=GosaviLeucoencephalopathymethotrexatestroke mimic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tushar D Gosavi Mohammed Tauqeer Ahmad Lai-Heng Lee Shih-Hui Lim |
spellingShingle |
Tushar D Gosavi Mohammed Tauqeer Ahmad Lai-Heng Lee Shih-Hui Lim Methotrexate induced leucoencephalopathy: A stroke mimic Annals of Indian Academy of Neurology Leucoencephalopathy methotrexate stroke mimic |
author_facet |
Tushar D Gosavi Mohammed Tauqeer Ahmad Lai-Heng Lee Shih-Hui Lim |
author_sort |
Tushar D Gosavi |
title |
Methotrexate induced leucoencephalopathy: A stroke mimic |
title_short |
Methotrexate induced leucoencephalopathy: A stroke mimic |
title_full |
Methotrexate induced leucoencephalopathy: A stroke mimic |
title_fullStr |
Methotrexate induced leucoencephalopathy: A stroke mimic |
title_full_unstemmed |
Methotrexate induced leucoencephalopathy: A stroke mimic |
title_sort |
methotrexate induced leucoencephalopathy: a stroke mimic |
publisher |
Wolters Kluwer Medknow Publications |
series |
Annals of Indian Academy of Neurology |
issn |
0972-2327 1998-3549 |
publishDate |
2013-01-01 |
description |
With increasing usage of thrombolysis in the treatment of acute ischemic strokes within 4.5- hour window, it is becoming more important to recognize stroke mimics. Though the incidence of stroke mimics being thrombolysed is less than 3%, it is essential to diagnose them so as to avoid wrong thrombolytic treatment which carries potential complications of bleeding. We describe the case of a 17 year old girl with acute lymphoblastic leukemia, who developed stroke like episodes on two consecutive challenges with a chemotherapeutic regime which included intravenous and intrathecal methotrexate. She had MRI changes consistent with acute ischemic stroke on both occasions. Her deficits recovered completely and spontaneously, as did the MRI changes. She did not have any further episodes when methotrexate was excluded from the chemotherapeutic regime. |
topic |
Leucoencephalopathy methotrexate stroke mimic |
url |
http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=3;spage=418;epage=421;aulast=Gosavi |
work_keys_str_mv |
AT tushardgosavi methotrexateinducedleucoencephalopathyastrokemimic AT mohammedtauqeerahmad methotrexateinducedleucoencephalopathyastrokemimic AT laihenglee methotrexateinducedleucoencephalopathyastrokemimic AT shihhuilim methotrexateinducedleucoencephalopathyastrokemimic |
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1725592209368023040 |