Tumor-Associated Lymphatic Vessel Features and Immunomodulatory Functions

Tumor-Associated Lymphatic Vessel Features and Immunomodulatory Functions

The lymphatic system comprises a network of lymphoid tissues and vessels that drains the extracellular compartment of most tissues. During tumor development, lymphatic endothelial cells (LECs) substantially expand in response to VEGFR-3 engagement by VEGF-C produced in the tumor microenvironment, a...

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Bibliographic Details
Main Authors: Laure Garnier, Anastasia-Olga Gkountidi, Stephanie Hugues
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
lymphatic vessels
anti-tumor immune response
metastasis
lymphangiogenesis
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00720/full

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