CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses.
Stimulating naïve CD8+ T cells with specific antigens and costimulatory signals is insufficient to induce optimal clonal expansion and effector functions. In this study, we show that the activation and differentiation of CD8+ T cells require IL-2 provided by activated CD4+ T cells at the initial pri...
Main Authors: | Yo-Ping Lai, Chia-Ching Lin, Wan-Jung Liao, Chih-Yung Tang, Shu-Ching Chen |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-11-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2770320?pdf=render |
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