The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair

The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair

The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance...

Full description

Bibliographic Details
Main Authors: Sonia Jimeno, Fernando R. Balestra, Pablo Huertas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
RNA modification
DNA repair
homologous recombination
DNA resection
R-loop
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.664872/full
Description
Summary:The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field.
ISSN:2296-889X

Similar Items