The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres.
Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB). Here, we report that the association of the telomerase su...
Main Authors: | Jane A Phillips, Angela Chan, Katrin Paeschke, Virginia A Zakian |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-04-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4408051?pdf=render |
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